Literature DB >> 28100594

Rapid Aminoglycoside NP Test for Rapid Detection of Multiple Aminoglycoside Resistance in Enterobacteriaceae.

Patrice Nordmann1,2, Aurélie Jayol3,4, Jan Dobias3, Laurent Poirel3.   

Abstract

The rapid aminoglycoside NP (Nordmann/Poirel) test was developed to rapidly identify multiple aminoglycoside (AG) resistance in Enterobacteriaceae It is based on the detection of the glucose metabolism related to enterobacterial growth in the presence of a defined concentration of amikacin plus gentamicin. Formation of acid metabolites was evidenced by a color change (orange to yellow) of the red phenol pH indicator. The rapid aminoglycoside NP test was evaluated by using bacterial colonies of 18 AG-resistant isolates producing 16S rRNA methylases, 20 AG-resistant isolates expressing AG-modifying enzymes (acetyl-, adenyl-, and phosphotransferases), and 10 isolates susceptible to AG. Its sensitivity and specificity were 100% and 97%, respectively, compared to the broth dilution method, which was taken as the gold standard for determining aminoglycoside resistance. The test is inexpensive, rapid (<2 h), and implementable worldwide.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  16S rRNA methylases; amikacin; antibiotic; gentamicin; kanamycin; netilmicin; plazomicin; rapid diagnostic test; susceptibility testing; tobramycin

Mesh：

Substances：

Year:  2017        PMID： 28100594      PMCID： PMC5377834          DOI： 10.1128/JCM.02107-16

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  11 in total

1.  The taxonomic significance of fermentative versus oxidative metabolism of carbohydrates by various gram negative bacteria.

Authors:  R HUGH; E LEIFSON
Journal:  J Bacteriol       Date:  1953-07       Impact factor: 3.490

2.  Updated multiplex polymerase chain reaction for detection of 16S rRNA methylases: high prevalence among NDM-1 producers.

Authors:  Béatrice Berçot; Laurent Poirel; Patrice Nordmann
Journal:  Diagn Microbiol Infect Dis       Date:  2011-10-13       Impact factor: 2.803

Review 3.  Therapeutic options for infections with Enterobacteriaceae producing carbapenem-hydrolyzing enzymes.

Authors:  Matthew E Falagas; Drosos E Karageorgopoulos; Patrice Nordmann
Journal:  Future Microbiol       Date:  2011-06       Impact factor: 3.165

4.  Distribution of 16S rRNA methylases among different species of Gram-negative bacilli with high-level resistance to aminoglycosides.

Authors:  Y Zhou; H Yu; Q Guo; X Xu; X Ye; S Wu; Y Guo; M Wang
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2010-07-08       Impact factor: 3.267

Review 5.  Comparison of the next-generation aminoglycoside plazomicin to gentamicin, tobramycin and amikacin.

Authors:  George G Zhanel; Christopher D Lawson; Sheryl Zelenitsky; Brandon Findlay; Frank Schweizer; Heather Adam; Andrew Walkty; Ethan Rubinstein; Alfred S Gin; Daryl J Hoban; Joseph P Lynch; James A Karlowsky
Journal:  Expert Rev Anti Infect Ther       Date:  2012-04       Impact factor: 5.091

6.  Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides.

Authors:  Jun-ichi Wachino; Keigo Shibayama; Hiroshi Kurokawa; Kouji Kimura; Kunikazu Yamane; Satowa Suzuki; Naohiro Shibata; Yasuyoshi Ike; Yoshichika Arakawa
Journal:  Antimicrob Agents Chemother       Date:  2007-09-17       Impact factor: 5.191

Review 7.  Aminoglycoside Resistance: The Emergence of Acquired 16S Ribosomal RNA Methyltransferases.

Authors:  Yohei Doi; Jun-Ichi Wachino; Yoshichika Arakawa
Journal:  Infect Dis Clin North Am       Date:  2016-06       Impact factor: 5.982

8.  Association between the Presence of Aminoglycoside-Modifying Enzymes and In Vitro Activity of Gentamicin, Tobramycin, Amikacin, and Plazomicin against Klebsiella pneumoniae Carbapenemase- and Extended-Spectrum-β-Lactamase-Producing Enterobacter Species.

Authors:  Ghady Haidar; Ammar Alkroud; Shaoji Cheng; Travis M Churilla; Bryce M Churilla; Ryan K Shields; Yohei Doi; Cornelius J Clancy; M Hong Nguyen
Journal:  Antimicrob Agents Chemother       Date:  2016-08-22       Impact factor: 5.191

Review 9.  Global spread of Carbapenemase-producing Enterobacteriaceae.

Authors:  Patrice Nordmann; Thierry Naas; Laurent Poirel
Journal:  Emerg Infect Dis       Date:  2011-10       Impact factor: 6.883

10.  RmtC and RmtF 16S rRNA Methyltransferase in NDM-1-Producing Pseudomonas aeruginosa.

Authors:  Mohibur Rahman; Kashi Nath Prasad; Ashutosh Pathak; Binod Kumar Pati; Avinash Singh; Cristina M Ovejero; Saheem Ahmad; Bruno Gonzalez-Zorn
Journal:  Emerg Infect Dis       Date:  2015-11       Impact factor: 6.883
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  7 in total

Review 1.  Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for the Rapid Detection of Antimicrobial Resistance Mechanisms and Beyond.

Authors:  Marina Oviaño; Germán Bou
Journal:  Clin Microbiol Rev       Date:  2018-11-28       Impact factor: 26.132

2.  High Rate of Association of 16S rRNA Methylases and Carbapenemases in Enterobacteriaceae Recovered from Hospitalized Children in Angola.

Authors:  Laurent Poirel; Juliette Goutines; Marta Aires-de-Sousa; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2018-03-27       Impact factor: 5.191

3.  Rapid ResaCeftazidime-Avibactam Enterobacterales NP Test: Rapid Detection of Ceftazidime-Avibactam Susceptibility in Enterobacterales.

Authors:  Luozhu Feng; Yining Zhao; Zhuocheng Yao; Xiaodong Zhang; Shufang Zheng; Lijiang Chen; Ying Zhang; Lingbo Wang; Tieli Zhou; Jianming Cao
Journal:  J Clin Microbiol       Date:  2022-08-10       Impact factor: 11.677

4.  Rapid and Accurate Detection of Aminoglycoside-Modifying Enzymes and 16S rRNA Methyltransferases by Targeted Liquid Chromatography-Tandem Mass Spectrometry.

Authors:  Dimard E Foudraine; Nikolaos Strepis; Corné H W Klaassen; Merel N Raaphorst; Annelies Verbon; Theo M Luider; Wil H F Goessens; Lennard J M Dekker
Journal:  J Clin Microbiol       Date:  2021-06-18       Impact factor: 5.948

5.  The Synergistic Activity and Optimizing Doses of Tigecycline in Combination with Aminoglycosides against Clinical Carbapenem-Resistant Klebsiella pneumoniae Isolates.

Authors:  Parnrada Nulsopapon; Worapong Nasomsong; Manat Pongchaidecha; Dhitiwat Changpradub; Piraporn Juntanawiwat; Wichai Santimaleeworagun
Journal:  Antibiotics (Basel)       Date:  2021-06-17

Review 6.  Plazomicin: a new aminoglycoside in the fight against antimicrobial resistance.

Authors:  Justin A Clark; David S Burgess
Journal:  Ther Adv Infect Dis       Date:  2020-09-04

7.  Increasing Trends of Association of 16S rRNA Methylases and Carbapenemases in Enterobacterales Clinical Isolates from Switzerland, 2017-2020.

Authors:  Claudine Fournier; Laurent Poirel; Sarah Despont; Julie Kessler; Patrice Nordmann
Journal:  Microorganisms       Date:  2022-03-14
  7 in total

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