Literature DB >> 28100393

Melanoma mystery.

Roger J Davis1.   

Abstract

Biological variability has confounded efforts to confirm the role of PREX2 mutations in melanoma.

Entities:  

Keywords:  Reproducibility Project: Cancer Biology; cancer biology; driver mutation; melanoma; metascience; mouse; replication; reproducibility

Mesh：

Substances：

Year:  2017        PMID： 28100393      PMCID： PMC5245955          DOI： 10.7554/eLife.22662

Source DB:  PubMed          Journal:  Elife        ISSN： 2050-084X            Impact factor:   8.140


  14 in total

1.  A meta-analysis of somatic mutations from next generation sequencing of 241 melanomas: a road map for the study of genes with potential clinical relevance.

Authors:  Junfeng Xia; Peilin Jia; Katherine E Hutchinson; Kimberly B Dahlman; Douglas Johnson; Jeffrey Sosman; William Pao; Zhongming Zhao
Journal:  Mol Cancer Ther       Date:  2014-04-22       Impact factor: 6.261

2.  A landscape of driver mutations in melanoma.

Authors:  Eran Hodis; Ian R Watson; Gregory V Kryukov; Stefan T Arold; Marcin Imielinski; Jean-Philippe Theurillat; Elizabeth Nickerson; Daniel Auclair; Liren Li; Chelsea Place; Daniel Dicara; Alex H Ramos; Michael S Lawrence; Kristian Cibulskis; Andrey Sivachenko; Douglas Voet; Gordon Saksena; Nicolas Stransky; Robert C Onofrio; Wendy Winckler; Kristin Ardlie; Nikhil Wagle; Jennifer Wargo; Kelly Chong; Donald L Morton; Katherine Stemke-Hale; Guo Chen; Michael Noble; Matthew Meyerson; John E Ladbury; Michael A Davies; Jeffrey E Gershenwald; Stephan N Wagner; Dave S B Hoon; Dirk Schadendorf; Eric S Lander; Stacey B Gabriel; Gad Getz; Levi A Garraway; Lynda Chin
Journal:  Cell       Date:  2012-07-20       Impact factor: 41.582

3.  PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion.

Authors:  Sarah M Mense; Douglas Barrows; Cindy Hodakoski; Nicole Steinbach; David Schoenfeld; William Su; Benjamin D Hopkins; Tao Su; Barry Fine; Hanina Hibshoosh; Ramon Parsons
Journal:  Sci Signal       Date:  2015-03-31       Impact factor: 8.192

4.  DNA methylation and gene deletion analysis of brain metastases in melanoma patients identifies mutually exclusive molecular alterations.

Authors:  Diego M Marzese; Richard A Scolyer; Maria Roqué; Laura M Vargas-Roig; Jamie L Huynh; James S Wilmott; Rajmohan Murali; Michael E Buckland; Garni Barkhoudarian; John F Thompson; Donald L Morton; Daniel F Kelly; Dave S B Hoon
Journal:  Neuro Oncol       Date:  2014-06-26       Impact factor: 12.300

5.  Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a.

Authors:  Barry Fine; Cindy Hodakoski; Susan Koujak; Tao Su; Lao H Saal; Matthew Maurer; Benjamin Hopkins; Megan Keniry; Maria Luisa Sulis; Sarah Mense; Hanina Hibshoosh; Ramon Parsons
Journal:  Science       Date:  2009-09-04       Impact factor: 47.728

6.  Whole genome sequencing of matched primary and metastatic acral melanomas.

Authors:  Samra Turajlic; Simon J Furney; Maryou B Lambros; Costas Mitsopoulos; Iwanka Kozarewa; Felipe C Geyer; Alan Mackay; Jarle Hakas; Marketa Zvelebil; Christopher J Lord; Alan Ashworth; Meirion Thomas; Gordon Stamp; James Larkin; Jorge S Reis-Filho; Richard Marais
Journal:  Genome Res       Date:  2011-12-19       Impact factor: 9.043

7.  Replication Study: Melanoma genome sequencing reveals frequent PREX2 mutations.

Authors:  Stephen K Horrigan; Pascal Courville; Darryl Sampey; Faren Zhou; Steve Cai
Journal:  Elife       Date:  2017-01-19       Impact factor: 8.140

8.  Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis.

Authors:  Cindy Hodakoski; Benjamin D Hopkins; Douglas Barrows; Sarah M Mense; Megan Keniry; Karen E Anderson; Philip A Kern; Phillip T Hawkins; Len R Stephens; Ramon Parsons
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-23       Impact factor: 11.205

9.  Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.

Authors:  Michael Krauthammer; Yong Kong; Byung Hak Ha; Perry Evans; Antonella Bacchiocchi; James P McCusker; Elaine Cheng; Matthew J Davis; Gerald Goh; Murim Choi; Stephan Ariyan; Deepak Narayan; Ken Dutton-Regester; Ana Capatana; Edna C Holman; Marcus Bosenberg; Mario Sznol; Harriet M Kluger; Douglas E Brash; David F Stern; Miguel A Materin; Roger S Lo; Shrikant Mane; Shuangge Ma; Kenneth K Kidd; Nicholas K Hayward; Richard P Lifton; Joseph Schlessinger; Titus J Boggon; Ruth Halaban
Journal:  Nat Genet       Date:  2012-07-29       Impact factor: 38.330

10.  Registered report: Melanoma genome sequencing reveals frequent PREX2 mutations.

Authors:  Denise Chroscinski; Darryl Sampey; Alex Hewitt
Journal:  Elife       Date:  2014-12-10       Impact factor: 8.140
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  1 in total

1.  The challenges of replication.

Authors: 
Journal:  Elife       Date:  2017-01-19       Impact factor: 8.140
  1 in total

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