Jaewon Yang1, Mehdi Khalighi2, Thomas A Hope1,3, Karen Ordovas1, Youngho Seo1,4,5. 1. Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA. 2. Applied Science Lab, GE Healthcare, Menlo Park, CA, USA. 3. Department of Radiology, San Francisco VA Medical Center, San Francisco, CA, USA. 4. Joint Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA, USA. 5. Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.
Abstract
PURPOSE: The study aims to demonstrate the feasibility of fast respiratory motion estimation using singles data available as a sorted format in list-mode files acquired in an integrated positron emission tomography/magnetic resonance imaging (PET/MRI) system for a proof-of-concept. METHODS: The derivation of singles-driven respiratory motion (SDRM) is enabled by singles recorded and binned by second for each detector crystal in PET list-mode data acquired in a SIGNA PET/MR. The proposed method is to derive a SDRM trace by summing up all singles from all detectors through the PET data acquisition. To assess the feasibility of SDRM for data-driven gating (DDG), SDRM traces were derived from the list-mode data acquired in five liver-focused 68 Ga-DOTA-TOC PET/MRI scans, and compared with the traces derived from bellows (pressure belt). Pearson's correlation coefficients and trigger time differences at peak-inhalation phases between SDRM and bellows traces were measured for quantitative evaluation. RESULTS: The method presented the average processing time of 4.2 ± 0.42 s (range: 3.9 ~ 4.7 s) for the derivation of SDRM traces. The majority of the time was spent for reading singles data from a list-mode file (3.1 ± 0.40 s, range: 2.7 ~ 3.7s). On average, the correlation coefficient of SDRM and bellows traces was 0.69 ± 0.16 (range: 0.41 ~ 0.80) and the time offset of SDRM-driven triggers from bellows-driven triggers was 0.25 ± 0.39 s (range: -0.85 ~ 2.69 s later than bellows triggers), demonstrating the similar patterns and phases of SDRM and bellows traces. CONCLUSIONS: We introduced PET singles-driven respiratory motion (SDRM) estimation as a proof-of-principle, using sorted singles ready for immediate processing in list-mode data. The results demonstrated the feasibility of SDRM and its potential use for gated PET with fast processing time.
PURPOSE: The study aims to demonstrate the feasibility of fast respiratory motion estimation using singles data available as a sorted format in list-mode files acquired in an integrated positron emission tomography/magnetic resonance imaging (PET/MRI) system for a proof-of-concept. METHODS: The derivation of singles-driven respiratory motion (SDRM) is enabled by singles recorded and binned by second for each detector crystal in PET list-mode data acquired in a SIGNA PET/MR. The proposed method is to derive a SDRM trace by summing up all singles from all detectors through the PET data acquisition. To assess the feasibility of SDRM for data-driven gating (DDG), SDRM traces were derived from the list-mode data acquired in five liver-focused 68 Ga-DOTA-TOC PET/MRI scans, and compared with the traces derived from bellows (pressure belt). Pearson's correlation coefficients and trigger time differences at peak-inhalation phases between SDRM and bellows traces were measured for quantitative evaluation. RESULTS: The method presented the average processing time of 4.2 ± 0.42 s (range: 3.9 ~ 4.7 s) for the derivation of SDRM traces. The majority of the time was spent for reading singles data from a list-mode file (3.1 ± 0.40 s, range: 2.7 ~ 3.7s). On average, the correlation coefficient of SDRM and bellows traces was 0.69 ± 0.16 (range: 0.41 ~ 0.80) and the time offset of SDRM-driven triggers from bellows-driven triggers was 0.25 ± 0.39 s (range: -0.85 ~ 2.69 s later than bellows triggers), demonstrating the similar patterns and phases of SDRM and bellows traces. CONCLUSIONS: We introduced PET singles-driven respiratory motion (SDRM) estimation as a proof-of-principle, using sorted singles ready for immediate processing in list-mode data. The results demonstrated the feasibility of SDRM and its potential use for gated PET with fast processing time.
Authors: Mojtaba Jafari Tadi; Eero Lehtonen; Jarmo Teuho; Juho Koskinen; Jussi Schultz; Reetta Siekkinen; Tero Koivisto; Mikko Pänkäälä; Mika Teräs; Riku Klén Journal: Sensors (Basel) Date: 2019-09-24 Impact factor: 3.576