Mahdi Sepidarkish1, Amir Almasi-Hashiani1, Saman Maroufizadeh1, Samira Vesali1, Reihaneh Pirjani2, Reza O Samani2. 1. Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. 2. Division of Perinatology, Department of Obstetrics and Gynecology, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Abstract
OBJECTIVE: To determine the impact of a history of spontaneous abortion on pre-eclampsia during a subsequent pregnancy. METHODS: A cross-sectional study enrolled pregnant women admitted to obstetrics and gynecology wards at 103 hospitals in Tehran, Iran for delivery between July 6 and July 21, 2015. Consenting participants were interviewed by midwives; data were collected using a five-part questionnaire and patients' medical records were retrieved. Patient data were analyzed by multiple logistic regression to identify variables associated with increased odds of pre-eclampsia. RESULTS: In total, 5170 patients were interviewed and 252 had experienced pre-eclampsia. The number of previous spontaneous abortions was found to be associated with pre-eclampsia, and a higher number of previous spontaneous abortions was associated with increased odds of patients having experienced pre-eclampsia (adjusted odds ratio 1.28, 95% confidence interval 1.03-1.59; P=0.025). CONCLUSION: A history of spontaneous abortion was associated with increased odds of pre-eclampsia during a subsequent pregnancy.
OBJECTIVE: To determine the impact of a history of spontaneous abortion on pre-eclampsia during a subsequent pregnancy. METHODS: A cross-sectional study enrolled pregnant women admitted to obstetrics and gynecology wards at 103 hospitals in Tehran, Iran for delivery between July 6 and July 21, 2015. Consenting participants were interviewed by midwives; data were collected using a five-part questionnaire and patients' medical records were retrieved. Patient data were analyzed by multiple logistic regression to identify variables associated with increased odds of pre-eclampsia. RESULTS: In total, 5170 patients were interviewed and 252 had experienced pre-eclampsia. The number of previous spontaneous abortions was found to be associated with pre-eclampsia, and a higher number of previous spontaneous abortions was associated with increased odds of patients having experienced pre-eclampsia (adjusted odds ratio 1.28, 95% confidence interval 1.03-1.59; P=0.025). CONCLUSION: A history of spontaneous abortion was associated with increased odds of pre-eclampsia during a subsequent pregnancy.