Jesús Villar1, Robert M Kacmarek. 1. CIBER de Enfermedades Respiratorias Instituto de Salud Carlos III Madrid, Spain; and Multidisciplinary Organ Dysfunction Evaluation Research Network Research Unit Hospital Universitario Dr. Negrín Las Palmas de Gran Canaria, Spain Department of Respiratory Care Massachusetts General Hospital; and Department of Anesthesiology Harvard University Boston, MA.