Literature DB >> 28098577

Mitochondria Initiate and Regulate Sarcopenia.

Stephen E Alway1, Junaith S Mohamed, Matthew J Myers.   

Abstract

We present the hypothesis that an accumulation of dysfunctional mitochondria initiates a signaling cascade leading to motor neuron and muscle fiber death and culminating in sarcopenia. Interactions between neural and muscle cells that contain dysfunctional mitochondria exacerbate sarcopenia. Preventing sarcopenia will require identifying mitochondrial sources of dysfunction that are reversible.

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Year:  2017        PMID： 28098577      PMCID： PMC5357179          DOI： 10.1249/JES.0000000000000101

Source DB:  PubMed          Journal:  Exerc Sport Sci Rev        ISSN： 0091-6331            Impact factor:   6.230


  150 in total

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