| Literature DB >> 28098317 |
Cheng-Peng Sun1, Andrei G Kutateladze2, Feng Zhao3, Li-Xia Chen4, Feng Qiu1.
Abstract
A novel withanolide, aromaphysalin A (1), possessing an exceptional C(11)-C(15) bond and an unprecedented 4,9-cyclized aromatic ring (ring A), is isolated from stems and leaves of Physalis angulata L. Its structure was determined by a combination of HRESIMS, 2D NMR spectra, and theoretical calculations. Compound 1 exhibited inhibitory activity on NO production with an IC50 value of 51.64 μM. A plausible biosynthetic pathway for 1 is also discussed.Entities:
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Year: 2017 PMID： 28098317 DOI： 10.1039/c6ob02656g
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876