Literature DB >> 28097756

AAZTA: An Ideal Chelating Agent for the Development of 44 Sc PET Imaging Agents.

Gábor Nagy1,2, Dezső Szikra1,2, György Trencsényi1,2, Anikó Fekete2, Ildikó Garai1, Arianna M Giani3, Roberto Negri3, Norberto Masciocchi4, Alessandro Maiocchi5, Fulvio Uggeri5, Imre Tóth6, Silvio Aime7, Giovanni B Giovenzana3,8, Zsolt Baranyai5,6.   

Abstract

Unprecedented fast and efficient complexation of ScIII was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the 44 Sc(AAZTA)- chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  PET; kinetics; radiopharmaceuticals; scandium; thermodynamics

Year:  2017        PMID： 28097756     DOI： 10.1002/anie.201611207

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  10 in total

1.  Synthesis, Physicochemical, Labeling and In Vivo Characterization of 44Sc-Labeled DO3AM-NI as a Hypoxia-Sensitive PET Probe.

Authors:  Dániel Szücs; Tibor Csupász; Judit P Szabó; Adrienn Kis; Barbara Gyuricza; Viktória Arató; Viktória Forgács; Adrienn Vágner; Gábor Nagy; Ildikó Garai; Dezső Szikra; Imre Tóth; György Trencsényi; Gyula Tircsó; Anikó Fekete
Journal:  Pharmaceuticals (Basel)       Date:  2022-05-26

2.  [nat/44Sc(pypa)]-: Thermodynamic Stability, Radiolabeling, and Biodistribution of a Prostate-Specific-Membrane-Antigen-Targeting Conjugate.

Authors:  Lily Li; María de Guadalupe Jaraquemada-Peláez; Eduardo Aluicio-Sarduy; Xiaozhu Wang; Dawei Jiang; Meelad Sakheie; Hsiou-Ting Kuo; Todd E Barnhart; Weibo Cai; Valery Radchenko; Paul Schaffer; Kuo-Shyan Lin; Jonathan W Engle; François Bénard; Chris Orvig
Journal:  Inorg Chem       Date:  2020-01-24       Impact factor: 5.165

3.  ImmunoPET: Concept, Design, and Applications.

Authors:  Weijun Wei; Zachary T Rosenkrans; Jianjun Liu; Gang Huang; Quan-Yong Luo; Weibo Cai
Journal:  Chem Rev       Date:  2020-03-23       Impact factor: 60.622

Review 4.  Highlights lecture EANM 2016: "Embracing molecular imaging and multi-modal imaging: a smart move for nuclear medicine towards personalized medicine".

Authors:  Eric O Aboagye; Françoise Kraeber-Bodéré
Journal:  Eur J Nucl Med Mol Imaging       Date:  2017-06-08       Impact factor: 9.236

5.  Effect of the versatile bifunctional chelator AAZTA5 on the radiometal labelling properties and the in vitro performance of a gastrin releasing peptide receptor antagonist.

Authors:  Michael Hofstetter; Euy Sung Moon; Fabio D'Angelo; Lucien Geissbühler; Ian Alberts; Ali Afshar-Oromieh; Frank Rösch; Axel Rominger; Eleni Gourni
Journal:  EJNMMI Radiopharm Chem       Date:  2020-11-30

6.  Hybrid Chelator-Based PSMA Radiopharmaceuticals: Translational Approach.

Authors:  Hanane Lahnif; Tilmann Grus; Stefanie Pektor; Lukas Greifenstein; Mathias Schreckenberger; Frank Rösch
Journal:  Molecules       Date:  2021-10-20       Impact factor: 4.411

Review 7.  AAZTA-Derived Chelators for the Design of Innovative Radiopharmaceuticals with Theranostic Applications.

Authors:  Cyril Fersing; Nicolas Masurier; Léa Rubira; Emmanuel Deshayes; Vincent Lisowski
Journal:  Pharmaceuticals (Basel)       Date:  2022-02-16

8.  PET Probes for Preclinical Imaging of GRPR-Positive Prostate Cancer: Comparative Preclinical Study of [68Ga]Ga-NODAGA-AMBA and [44Sc]Sc-NODAGA-AMBA.

Authors:  Ibolya Kálmán-Szabó; Judit P Szabó; Viktória Arató; Noémi Dénes; Gábor Opposits; István Jószai; István Kertész; Zita Képes; Anikó Fekete; Dezső Szikra; István Hajdu; György Trencsényi
Journal:  Int J Mol Sci       Date:  2022-09-02       Impact factor: 6.208

9.  AAZTA5/AAZTA5-TOC: synthesis and radiochemical evaluation with 68Ga, 44Sc and 177Lu.

Authors:  Jean-Philippe Sinnes; Johannes Nagel; Frank Rösch
Journal:  EJNMMI Radiopharm Chem       Date:  2019-08-01

10.  Chelation with a twist: a bifunctional chelator to enable room temperature radiolabeling and targeted PET imaging with scandium-44.

Authors:  Brett A Vaughn; Shin Hye Ahn; Eduardo Aluicio-Sarduy; Justin Devaraj; Aeli P Olson; Jonathan Engle; Eszter Boros
Journal:  Chem Sci       Date:  2019-11-20       Impact factor: 9.825
  10 in total

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