Dean A Tripp1, J Curtis Nickel1, Adrijana Krsmanovic1, Michel Pontari2, Robert Moldwin3, Robert Mayer4, Lesley K Carr5, Claire C Yang6, Jorgen Nordling7. 1. Queen's University, Kingston, ON, Canada. 2. Temple University, Philadelphia, PA, United States. 3. Hofstra University School of Medicine, New Hyde Park, NY, United States. 4. Asante Physician Partners, Grants Pass, OR, United States. 5. University of Toronto, Toronto, ON, Canada. 6. University of Washington, Seattle, WA, United States. 7. University of Copenhagen, Herlev, Denmark.
Abstract
INTRODUCTION: We sought to evaluate psychosocial factors as predictors of suicidal ideation (SI) in a tertiary care outpatient sample of women suffering from interstitial cystitis/bladder pain syndrome (IC/BPS). METHODS: The patients are women managed at tertiary care centres (n=190). Controls were recruited from the community (n=117). Both groups completed questionnaires on demographics, pain (McGill Pain Questionnaire), IC/BPS symptoms, and psychological variables. Univariate and multivariate hierarchical regression modelling was conducted to examine the strength of associations and unique effects of psychosocial variables on patient SI. RESULTS: Compared to 6% in healthy controls, 23% of patients endorsed SI in the past two weeks. Correlations between SI, depression, and catastrophizing across controls and cases show that for controls, SI is associated with greater pain (0.31; p<0.01) and depression only (0.59; p<0.01). For tertiary care centre cases, SI is associated with pain (0.24; p<0.01), depression (0.64; p<0.01), and catastrophizing (0.35; p<0.01). Regression analyses indicated that psychosocial variables accounted for a significant amount of variance over and above IC/BPS symptoms. Catastrophizing (i.e., helplessness) about pain and depression were significant univariate predictors of SI, but only depression predicted SI in multivariable analyses. CONCLUSIONS: Limitations of this study include its cross-sectional design and primarily correlation-based statistics. The present study is the first to implicate multiple psychosocial risk factors over and above IC/BPS-specific symptoms and patient pain experience in SI in women with IC/BPS. Depression in particular is uniquely important in predicting suicidality. These results support a multidisciplinary, proactive approach to IC/BPS involving not only treatment of disease symptoms, but also early detection/treatment of associated psychosocial problems.
INTRODUCTION: We sought to evaluate psychosocial factors as predictors of suicidal ideation (SI) in a tertiary care outpatient sample of women suffering from interstitial cystitis/bladder pain syndrome (IC/BPS). METHODS: The patients are women managed at tertiary care centres (n=190). Controls were recruited from the community (n=117). Both groups completed questionnaires on demographics, pain (McGill Pain Questionnaire), IC/BPS symptoms, and psychological variables. Univariate and multivariate hierarchical regression modelling was conducted to examine the strength of associations and unique effects of psychosocial variables on patient SI. RESULTS: Compared to 6% in healthy controls, 23% of patients endorsed SI in the past two weeks. Correlations between SI, depression, and catastrophizing across controls and cases show that for controls, SI is associated with greater pain (0.31; p<0.01) and depression only (0.59; p<0.01). For tertiary care centre cases, SI is associated with pain (0.24; p<0.01), depression (0.64; p<0.01), and catastrophizing (0.35; p<0.01). Regression analyses indicated that psychosocial variables accounted for a significant amount of variance over and above IC/BPS symptoms. Catastrophizing (i.e., helplessness) about pain and depression were significant univariate predictors of SI, but only depression predicted SI in multivariable analyses. CONCLUSIONS: Limitations of this study include its cross-sectional design and primarily correlation-based statistics. The present study is the first to implicate multiple psychosocial risk factors over and above IC/BPS-specific symptoms and patientpain experience in SI in women with IC/BPS. Depression in particular is uniquely important in predicting suicidality. These results support a multidisciplinary, proactive approach to IC/BPS involving not only treatment of disease symptoms, but also early detection/treatment of associated psychosocial problems.
Authors: Dean A Tripp; J Curtis Nickel; Yanlin Wang; Mark S Litwin; Mary McNaughton-Collins; J Richard Landis; Richard B Alexander; Anthony J Schaeffer; Michael P O'Leary; Michel A Pontari; Jackson E Fowler; Leroy M Nyberg; John W Kusek Journal: J Pain Date: 2006-10 Impact factor: 5.820
Authors: Dean A Tripp; J Curtis Nickel; Jennifer Wong; Michel Pontari; Robert Moldwin; Robert Mayer; Lesley K Carr; Ragi Doggweiler; Claire C Yang; Nagendra Mishra; Jorgen Nordling Journal: Eur Urol Date: 2012-05-18 Impact factor: 20.096
Authors: Lindsey C McKernan; Colin G Walsh; William S Reynolds; Leslie J Crofford; Roger R Dmochowski; David A Williams Journal: Neurourol Urodyn Date: 2017-10-09 Impact factor: 2.696
Authors: Lindsey C McKernan; Kemberlee R Bonnet; Michael T M Finn; David A Williams; Stephen Bruehl; W Stuart Reynolds; Daniel Clauw; Roger R Dmochowski; David G Schlundt; Leslie J Crofford Journal: Can J Pain Date: 2020-09-01
Authors: Jeffrey M Lackner; James Jaccard; Brian M Quigley; Tova S Ablove; Teresa L Danforth; Rebecca S Firth; Gregory D Gudleski; Susan S Krasner; Christopher D Radziwon; Alison M Vargovich; J Quentin Clemens; Bruce D Naliboff Journal: Trials Date: 2022-08-13 Impact factor: 2.728
Authors: Linda Fischer-Grote; Vera Fössing; Martin Aigner; Markus Boeckle; Elisabeth Fehrmann Journal: Int Urogynecol J Date: 2022-03-09 Impact factor: 1.932
Authors: Dean A Tripp; Joel Dueck; Ronald R Holden; Julia Moreau; R Christopher Doiron; J Curtis Nickel Journal: Can Urol Assoc J Date: 2021-12 Impact factor: 1.862