Yu-Jie Zhou1,2, Hai Zou3, Ji-Na Zheng1,2, Tian-Tian Zou1,4, Alessandro Vitale5, Luca Miele6,7, Sven Van Poucke8, Wen-Yue Liu9, Shengrong Shen10, Dong-Chu Zhang11, Ke-Qing Shi1,12, Ming-Hua Zheng1,12. 1. a Department of Hepatology, Liver Research Center , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China. 2. b School of the First Clinical Medical Sciences , Wenzhou Medical University , Wenzhou , China. 3. c Department of Cardiology , Zhejiang Provincial People's Hospital , Hangzhou , China. 4. d School of the Second Clinical Medical Sciences , Wenzhou Medical University , Wenzhou , China. 5. e Department of Surgery, Oncology and Gastroenterology , University of Padua , Padua , Italy. 6. f Institute of Internal Medicine , Catholic University of Rome , Rome , Italy. 7. g Gastroenterology Area, Fondazione Policlinico Gemelli , Rome , Italy. 8. h Department of Anesthesiology , Critical Care, Emergency Medicine and Pain Therapy, Ziekenhuis Oost-Limburg , Genk , Belgium. 9. i Department of Endocrinology , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China. 10. j Department of Food Science & Nutrition , Zhejiang University , Hangzhou , China. 11. k Wenzhou Medical Center, Wenzhou People's Hospital , Wenzhou , China. 12. l Institute of Hepatology , Wenzhou Medical University , Wenzhou , China.
Abstract
BACKGROUND: Several risk factors are able to predict non-alcoholic fatty liver (NAFL) development, but the predictive value of serum alkaline phosphatase (ALP) remains uncertain. Our aim is to investigate the association between serum ALP levels and NAFL. METHODS: 21,331 NAFL-free subjects were included. Sex-specific ALP quartiles (Q1 to Q4) were defined. With Q1 used as reference, hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated across each quartile. RESULTS: After adjusting for confounding variables, values in Q2, Q3 and Q4 had HRs (95%CIs) of 1.16 (0.94-1.43), 1.38 (1.13-1.69), 1.51 (1.24-1.83) in females and 0.99 (0.90-1.09), 1.04 (0.95-1.14), 0.96 (0.87-1.05) in males, respectively. A subgroup analysis of age factors in females, from Q2 to Q4, adjusted HRs (95%CIs) were 1.31 (0.81-1.99), 1.86 (1.23-2.81), 2.44 (1.60-3.71) in their 30 s, 1.13 (0.83-1.54), 1.17 (0.85-1.62), 1.65 (1.22-2.25) in their 40 s, and 0.95 (0.51-1.78), 0.91 (0.52-1.62), 0.89 (0.53-1.52) in their 50 s. CONCLUSIONS: Higher serum ALP levels are considered a significant predictor for NAFL development in females aged 30 to 50.
BACKGROUND: Several risk factors are able to predict non-alcoholic fatty liver (NAFL) development, but the predictive value of serum alkaline phosphatase (ALP) remains uncertain. Our aim is to investigate the association between serum ALP levels and NAFL. METHODS: 21,331 NAFL-free subjects were included. Sex-specific ALP quartiles (Q1 to Q4) were defined. With Q1 used as reference, hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated across each quartile. RESULTS: After adjusting for confounding variables, values in Q2, Q3 and Q4 had HRs (95%CIs) of 1.16 (0.94-1.43), 1.38 (1.13-1.69), 1.51 (1.24-1.83) in females and 0.99 (0.90-1.09), 1.04 (0.95-1.14), 0.96 (0.87-1.05) in males, respectively. A subgroup analysis of age factors in females, from Q2 to Q4, adjusted HRs (95%CIs) were 1.31 (0.81-1.99), 1.86 (1.23-2.81), 2.44 (1.60-3.71) in their 30 s, 1.13 (0.83-1.54), 1.17 (0.85-1.62), 1.65 (1.22-2.25) in their 40 s, and 0.95 (0.51-1.78), 0.91 (0.52-1.62), 0.89 (0.53-1.52) in their 50 s. CONCLUSIONS: Higher serum ALP levels are considered a significant predictor for NAFL development in females aged 30 to 50.
Entities:
Keywords:
Non-alcoholic fatty liver; age factors; alkaline phosphatase; risk factor; sex factors
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