Literature DB >> 28095062

MicroRNA-196a as a Potential Diagnostic Biomarker for Esophageal Squamous Cell Carcinoma.

Mona Fendereski1, Mohammad Farid Zia2, Mohammad Shafiee3, Forousan Safari1, Mohammad Hosien Saneie4, Manoochehr Tavassoli1.   

Abstract

We observed significant up-regulation of miR-196a in esophageal squamous cell carcinoma (ESCC) as compared with their adjacent normal tissue (p = .002). Receiver operating characteristics curve analysis confirmed the suitability of miR-196a as a potential tumor marker for diagnosis of ESCC. Furthermore, analysis of miR-196a levels in saliva samples determined an average of 27-fold up-regulations in ESCC patients compared with healthy group. Our results suggest that salivary miR-196a may be a suitable noninvasive biomarker for diagnosis of ESCC. In addition, molecular pathway enrichment analysis of microRNA (miR)-196a determined focal adhesion, spliceosome and p53 signaling pathways as the most relevant pathways with miR-196a targetome.

Entities:  

Keywords:  ESCC; biomarker; miR-196a; saliva

Mesh：

Substances：

Year:  2017        PMID： 28095062     DOI： 10.1080/07357907.2016.1254228

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  12 in total

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8.  Regulation of UGT2A1 by miR-196a-5p and miR-196b-5p.

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9.  Heterogeneity Analysis of Esophageal Squamous Cell Carcinoma in Cell Lines, Tumor Tissues and Patient-Derived Xenografts.

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Review 10.  Human salivary microRNAs in Cancer.

Authors:  Óscar Rapado-González; Blanca Majem; Laura Muinelo-Romay; Ana Álvarez-Castro; Anna Santamaría; Antonio Gil-Moreno; Rafael López-López; María Mercedes Suárez-Cunqueiro
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