Fernanda Viviane Mariano1, Renata Freitas Varanda2, Luciana Schultz3, Marcelo Brum Correa4, Oslei Paes de Almeida2, Albina Altemani5, Márcio Ajudarte Lopes2. 1. Pathology Department, Faculty of Medical Sciences, State University of Campinas, Brazil. Electronic address: fevimariano@gmail.com. 2. Oral Diagnosis Department, Piracicaba Dental School, State University of Campinas, Brazil. 3. Institute of Pathological Anatomy, Piracicaba-SP, Brazil. 4. Oncology Center, Fornecedores de Cana Hospital, Piracicaba-SP, Brazil. 5. Pathology Department, Faculty of Medical Sciences, State University of Campinas, Brazil.
Abstract
INTRODUCTION: Cribriform adenocarcinoma of the tongue and minor salivary glands (CATMSG) is a recently described entity, with most cases previously published as polymorphous low-grade adenocarcinoma (PLGA). Typical cases share some main characteristics, such as oral sites (mainly tongue), regional lymph node metastasis, and morphology resembling solid and follicular variants of papillary thyroid carcinoma. OBJECTIVE: To present a CATMSG and emphasize the importance of reclassifying PLGAs with unusual behavior. CASE REPORT: A 78-year-old male presented with an ulcerated mass in the soft palate treated as PLGA. The patient developed 5 regional metastases over 11 years of follow-up, all diagnosed as PLGA. He died due to the disease, and because of the very aggressive behavior of PLGA, all histopathologic slides were revised and the tumor was reclassified as CATMSG. CONCLUSION: This report emphasizes the importance of reevaluating aggressive PLGA and contributes to a better understanding of CATMSG.
INTRODUCTION: Cribriform adenocarcinoma of the tongue and minor salivary glands (CATMSG) is a recently described entity, with most cases previously published as polymorphous low-grade adenocarcinoma (PLGA). Typical cases share some main characteristics, such as oral sites (mainly tongue), regional lymph node metastasis, and morphology resembling solid and follicular variants of papillary thyroid carcinoma. OBJECTIVE: To present a CATMSG and emphasize the importance of reclassifying PLGAs with unusual behavior. CASE REPORT: A 78-year-old male presented with an ulcerated mass in the soft palate treated as PLGA. The patient developed 5 regional metastases over 11 years of follow-up, all diagnosed as PLGA. He died due to the disease, and because of the very aggressive behavior of PLGA, all histopathologic slides were revised and the tumor was reclassified as CATMSG. CONCLUSION: This report emphasizes the importance of reevaluating aggressive PLGA and contributes to a better understanding of CATMSG.
Authors: Ximena Mimica; Nora Katabi; Marlena R McGill; Ashley Hay; Daniella Karassawa Zanoni; Jatin P Shah; Richard J Wong; Marc A Cohen; Snehal G Patel; Ian Ganly Journal: Oral Oncol Date: 2019-06-07 Impact factor: 5.337