Literature DB >> 28094180

Antifungal activity of substituted aurones.

Caleb L Sutton1, Zachary E Taylor2, Mary B Farone3, Scott T Handy4.   

Abstract

Novel antifungals are in high demand as there is a growing resistance to antifungals currently in use. In particular, opportunistic fungal infections caused by Candida spp. are on the rise with infections by this genus accounting for the most severe fungal infections following chemotherapy, implantation procedures, and in patients with HIV/AIDS. A series of simple aurone analogs were synthesized and screened for antifungal activity versus Candida spp. Several compounds displayed activity at 100μM, with two having IC50 values below 20μM for three species of Candida. One of the compounds tested here also exhibits anti-biofilm activity for mid-maturation growth.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antifungal; Aurone; Biofilm; Candida albicans; Candida glabrata; Candida tropicalis

Mesh：

Substances：

Year:  2017        PMID： 28094180     DOI： 10.1016/j.bmcl.2017.01.012

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Herbal ethosomal gel containing luliconazole for productive relevance in the field of biomedicine.

Authors:  Vivek Dave; Nishant Bhardwaj; Nikita Gupta; Kajal Tak
Journal:  3 Biotech       Date:  2020-02-06       Impact factor: 2.406

2.  Transcriptome-Wide Identification of an Aurone Glycosyltransferase with Glycosidase Activity from Ornithogalum saundersiae.

Authors:  Shuai Yuan; Ming Liu; Yan Yang; Jiu-Ming He; Ya-Nan Wang; Jian-Qiang Kong
Journal:  Genes (Basel)       Date:  2018-06-28       Impact factor: 4.096

3.  3D-QSAR, docking and ADMET properties of aurone analogues as antimalarial agents.

Authors:  Hanine Hadni; Menana Elhallaoui
Journal:  Heliyon       Date:  2020-04-18

Review 4.  Aurones: A Golden Resource for Active Compounds.

Authors:  Ilaria Mazziotti; Giovanni Petrarolo; Concettina La Motta
Journal:  Molecules       Date:  2021-12-21       Impact factor: 4.411

5.  Chemogenomic profiling to understand the antifungal action of a bioactive aurone compound.

Authors:  Fatmah M Alqahtani; Brock A Arivett; Zachary E Taylor; Scott T Handy; Anthony L Farone; Mary B Farone
Journal:  PLoS One       Date:  2019-12-11       Impact factor: 3.240

6.  Exploring the 2'-Hydroxy-Chalcone Framework for the Development of Dual Antioxidant and Soybean Lipoxygenase Inhibitory Agents.

Authors:  Ioanna Kostopoulou; Andromachi Tzani; Nestor-Ioannis Polyzos; Maria-Anna Karadendrou; Eftichia Kritsi; Eleni Pontiki; Thalia Liargkova; Dimitra Hadjipavlou-Litina; Panagiotis Zoumpoulakis; Anastasia Detsi
Journal:  Molecules       Date:  2021-05-08       Impact factor: 4.411

7.  Combining Genome-Wide Gene Expression Analysis (RNA-seq) and a Gene Editing Platform (CRISPR-Cas9) to Uncover the Selectively Pro-oxidant Activity of Aurone Compounds Against Candida albicans.

Authors:  Fatmah M Alqahtani; Scott T Handy; Caleb L Sutton; Mary B Farone
Journal:  Front Microbiol       Date:  2021-07-15       Impact factor: 5.640
  7 in total

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