Literature DB >> 28094179

Synthesis and antiviral evaluation of novel heteroarylpyrimidines analogs as HBV capsid effectors.

Sebastien Boucle1, Xiao Lu1, Leda Bassit1, Tugba Ozturk1, Olivia Ollinger Russell1, Franck Amblard1, Steven J Coats2, Raymond F Schinazi3.   

Abstract

New modifications to the scaffold of previously reported HBV capsid assembly effectors such as BAY 41-4109, HAP-12 and GLS4 were explored. The anti-HBV activity in the HepAD38 system, and cytotoxicity profiles of each of the new compounds has been assessed. Among them, five new iodo- and bromo-heteroarylpyrimidines analogs displayed anti-HBV activity in the low micromolar range.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Capsid assembly effectors; HAP; HBV; Heteroarylpyrimidine

Mesh：

Substances：

Year:  2017        PMID： 28094179      PMCID： PMC5314961          DOI： 10.1016/j.bmcl.2017.01.010

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Global structural changes in hepatitis B virus capsids induced by the assembly effector HAP1.

Authors:  Christina R Bourne; M G Finn; Adam Zlotnick
Journal:  J Virol       Date:  2006-08-30       Impact factor: 5.103

Review 2.  Antihepatitis B therapy: a review of current medications and novel small molecule inhibitors.

Authors:  Li-Peng Qiu; Liang Chen; Ke-Ping Chen
Journal:  Fundam Clin Pharmacol       Date:  2013-11-18       Impact factor: 2.748

Review 3.  Toward Elimination of Hepatitis B Virus Using Novel Drugs, Approaches, and Combined Modalities.

Authors:  Sebastien Boucle; Leda Bassit; Maryam Ehteshami; Raymond F Schinazi
Journal:  Clin Liver Dis       Date:  2016-08-30       Impact factor: 6.126

4.  Antiviral activities and cellular toxicities of modified 2',3'-dideoxy-2',3'-didehydrocytidine analogues.

Authors:  Lieven J Stuyver; Stefania Lostia; Marjorie Adams; Judy S Mathew; Balakrishna S Pai; Jason Grier; Phillip M Tharnish; Yongseok Choi; Youhoon Chong; Hyunah Choo; Chung K Chu; Michael J Otto; Raymond F Schinazi
Journal:  Antimicrob Agents Chemother       Date:  2002-12       Impact factor: 5.191

5.  Preclinical characterization of GLS4, an inhibitor of hepatitis B virus core particle assembly.

Authors:  Guoyi Wu; Bo Liu; Yingjun Zhang; Jing Li; Alla Arzumanyan; Marcia M Clayton; Raymond F Schinazi; Zhaohe Wang; Siegfried Goldmann; Qingyun Ren; Faxhou Zhang; Mark A Feitelson
Journal:  Antimicrob Agents Chemother       Date:  2013-08-19       Impact factor: 5.191

6.  The main hepatitis B virus (HBV) mutants resistant to nucleoside analogs are susceptible in vitro to non-nucleoside inhibitors of HBV replication.

Authors:  Gaëtan Billioud; Christian Pichoud; Gerhard Puerstinger; Johan Neyts; Fabien Zoulim
Journal:  Antiviral Res       Date:  2011-08-18       Impact factor: 5.970

7.  Inhibition of hepatitis B virus replication by the internal fragment of hepatitis B core protein.

Authors:  Jinchao Han; Xiaoben Pan; Yan Gao; Lai Weil
Journal:  Virus Res       Date:  2010-03-18       Impact factor: 3.303

8.  Small-molecule effectors of hepatitis B virus capsid assembly give insight into virus life cycle.

Authors:  Christina Bourne; Sejin Lee; Bollu Venkataiah; Angela Lee; Brent Korba; M G Finn; Adam Zlotnick
Journal:  J Virol       Date:  2008-08-06       Impact factor: 5.103

9.  2,4-Diaryl-4,6,7,8-tetrahydroquinazolin-5(1H)-one derivatives as anti-HBV agents targeting at capsid assembly.

Authors:  Xuejun Zhu; Guoming Zhao; Xiaoping Zhou; Xiaoqian Xu; Guangqiang Xia; Zhibing Zheng; Lili Wang; Xiaohong Yang; Song Li
Journal:  Bioorg Med Chem Lett       Date:  2009-10-30       Impact factor: 2.823
  9 in total
  4 in total

1.  Discovery of a New Sulfonamide Hepatitis B Capsid Assembly Modulator.

Authors:  Hyo Gyeong Na; Ali Imran; Kyuneun Kim; Hong Sik Han; Young Jin Lee; Myung-Jin Kim; Chang-Soo Yun; Young-Sik Jung; Joo-Youn Lee; Soo Bong Han
Journal:  ACS Med Chem Lett       Date:  2020-01-09       Impact factor: 4.345

Review 2.  Updates on Chronic HBV: Current Challenges and Future Goals.

Authors:  Hannah M Lee; Bubu A Banini
Journal:  Curr Treat Options Gastroenterol       Date:  2019-06

3.  The Heteroaryldihydropyrimidine Bay 38-7690 Induces Hepatitis B Virus Core Protein Aggregates Associated with Promyelocytic Leukemia Nuclear Bodies in Infected Cells.

Authors:  Andrew D Huber; Jennifer J Wolf; Dandan Liu; Anna T Gres; Jing Tang; Kelsey N Boschert; Maritza N Puray-Chavez; Dallas L Pineda; Thomas G Laughlin; Emily M Coonrod; Qiongying Yang; Juan Ji; Karen A Kirby; Zhengqiang Wang; Stefan G Sarafianos
Journal:  mSphere       Date:  2018-04-18       Impact factor: 4.389

4.  Design and Synthesis of Hepatitis B Virus (HBV) Capsid Assembly Modulators and Evaluation of Their Activity in Mammalian Cell Model.

Authors:  Karina Spunde; Brigita Vigante; Unda Nelda Dubova; Anda Sipola; Irena Timofejeva; Anna Zajakina; Juris Jansons; Aiva Plotniece; Karlis Pajuste; Arkadij Sobolev; Ruslan Muhamadejev; Kristaps Jaudzems; Gunars Duburs; Tatjana Kozlovska
Journal:  Pharmaceuticals (Basel)       Date:  2022-06-22
  4 in total

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