J P Lindenmayer1, Samantha Fregenti2, Guoxin Kang3, Veronica Ozog4, Isidora Ljuri5, Anzalee Khan6, A Goldring7, Susan R McGurk8. 1. Manhattan Psychiatric Center, 600 E 125th Street, New York, NY 10035, United States; Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, United States; New York University, Department of Psychiatry, New York, NY, United States. Electronic address: Lindenmayer@nki.rfmh.org. 2. Manhattan Psychiatric Center, 600 E 125th Street, New York, NY 10035, United States. Electronic address: sefreg13@g.holycross.edu. 3. Manhattan Psychiatric Center, 600 E 125th Street, New York, NY 10035, United States; Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, United States. Electronic address: Guoxin.Kang1@gmail.com. 4. Manhattan Psychiatric Center, 600 E 125th Street, New York, NY 10035, United States; Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, United States. Electronic address: VOzog@nki.rfmh.org. 5. Manhattan Psychiatric Center, 600 E 125th Street, New York, NY 10035, United States; Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, United States. Electronic address: ILjuri@nki.rfmh.org. 6. Manhattan Psychiatric Center, 600 E 125th Street, New York, NY 10035, United States; Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, United States. Electronic address: AKhan@nki.rfmh.org. 7. Manhattan Psychiatric Center, 600 E 125th Street, New York, NY 10035, United States. Electronic address: AGoldring@nki.rfmh.org. 8. Boston University, Boston, MA, United States. Electronic address: mgurk@bu.edu.
Abstract
BACKGROUND: This study aims to examine the effects of change in neurocognition on functional outcomes and to examine predictors of change in social functions following a 12-week course of cognitive remediation in patients with schizophrenia and schizoaffective disorder with severe cognitive impairments. METHOD: Level of social functioning was assessed using a performance based measure of functional capacity (PSP) in patients prior to and after the completion of 12-week cognitive remediation treatment (CRT). Participants completed a neuropsychological battery (MCCB-MATRICS) and clinical measures at both time points. RESULTS: 63 subjects with a mean age of 41.4 (SD=12.2) and with 12.2years of education (SD=2.4) were enrolled. There were significant improvements in overall PSP score from baseline to endpoint (p=0.021) as well as in PSP domain A (socially useful activities) (p≤0.001), domain B (personal and social relationships) (p=0.009), and domain D (disturbing and aggressive behaviors) (p=0.003). There was a significant improvement in the composite MCCB score (p=0.020) and the Working Memory (p<0.046). Stepwise logistic regression yielded a significant association for baseline Visual Learning (Wald=6.537, p=0.011, OR=1.195), Speed of Processing (Wald=4.112, p=0.043, OR=0.850) and level of PANSS positive symptoms (Wald=4.087, p=0.043, OR=0.739) with PSP overall improvement. CONCLUSIONS: Faster speed of processing, better visual and verbal learning and less prominent positive symptoms were associated with greater functional improvement after a systematic cognitive intervention within a rehabilitative setting.
BACKGROUND: This study aims to examine the effects of change in neurocognition on functional outcomes and to examine predictors of change in social functions following a 12-week course of cognitive remediation in patients with schizophrenia and schizoaffective disorder with severe cognitive impairments. METHOD: Level of social functioning was assessed using a performance based measure of functional capacity (PSP) in patients prior to and after the completion of 12-week cognitive remediation treatment (CRT). Participants completed a neuropsychological battery (MCCB-MATRICS) and clinical measures at both time points. RESULTS: 63 subjects with a mean age of 41.4 (SD=12.2) and with 12.2years of education (SD=2.4) were enrolled. There were significant improvements in overall PSP score from baseline to endpoint (p=0.021) as well as in PSP domain A (socially useful activities) (p≤0.001), domain B (personal and social relationships) (p=0.009), and domain D (disturbing and aggressive behaviors) (p=0.003). There was a significant improvement in the composite MCCB score (p=0.020) and the Working Memory (p<0.046). Stepwise logistic regression yielded a significant association for baseline Visual Learning (Wald=6.537, p=0.011, OR=1.195), Speed of Processing (Wald=4.112, p=0.043, OR=0.850) and level of PANSS positive symptoms (Wald=4.087, p=0.043, OR=0.739) with PSP overall improvement. CONCLUSIONS: Faster speed of processing, better visual and verbal learning and less prominent positive symptoms were associated with greater functional improvement after a systematic cognitive intervention within a rehabilitative setting.
Authors: Lana K M Otto; Jacomijn Hofstra; Michelle G Mullen; Derek Malenczak; Nynke Boonstra; Lisette van der Meer; Wim Veling; Cees Boerhout; Gerard D van Rijsbergen; Jos de Vries; Boudien van der Pol; Gerdina H M Pijnenborg; Lies Korevaar Journal: Pilot Feasibility Stud Date: 2020-04-27
Authors: C Kossmann; J Heller; M Brüne; C Schulz; M Heinze; J Cordes; B Mühlbauer; E Rüther; J Timm; G Gründer; G Juckel Journal: Psychiatr Q Date: 2021-03