M Katsoulis1, V Benetou2, T Karapetyan1, D Feskanich3, F Grodstein3, U Pettersson-Kymmer4, S Eriksson5, T Wilsgaard6, L Jørgensen7, L A Ahmed7,8, B Schöttker9, H Brenner9, A Bellavia10, A Wolk10, R Kubinova11, B Stegeman12, M Bobak12, P Boffetta1,13, A Trichopoulou1. 1. Hellenic Health Foundation, Athens, Greece. 2. School of Medicine, Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Athens, Greece. 3. Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA. 4. Department of Pharmacology and Clinical Neurosciences and Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden. 5. Faculty of Medicine, Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden. 6. Department of Community Medicine, UIT The Arctic University of Norway, Tromsø, Norway. 7. Department of Health and Care Sciences, UIT The Arctic University of Norway, Tromsø, Norway. 8. Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE. 9. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany. 10. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. 11. National Institute of Public Health, Prague, Czech Republic. 12. Department of Epidemiology and Public Health, University College London, London, UK. 13. Institute for Translational Epidemiology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Abstract
BACKGROUND: Hip fractures are associated with diminished quality of life and survival especially amongst the elderly. OBJECTIVE: All-cause mortality after hip fracture was investigated to assess its magnitude. METHODS: A total of 122 808 participants from eight cohorts in Europe and the USA were followed up for a mean of 12.6 years, accumulating 4273 incident hip fractures and 27 999 deaths. Incident hip fractures were assessed through telephone interviews/questionnaires or national inpatient/fracture registries, and causes of death were verified with death certificates. Cox proportional hazards models and the time-dependent variable methodology were used to assess the association between hip fracture and mortality and its magnitude at different time intervals after the injury in each cohort. We obtained the effect estimates through a random-effects meta-analysis. RESULTS: Hip fracture was positively associated with increased all-cause mortality; the hazard ratio (HR) in the fully adjusted model was 2.12, 95% confidence interval (CI) 1.76-2.57, after adjusting for potential confounders. This association was stronger amongst men [HR: 2.39, 95% CI: 1.72-3.31] than amongst women [HR: 1.92, 95% CI: 1.54-2.39], although this difference was not significant. Mortality was higher during the first year after the hip fracture [HR: 2.78, 95% CI: 2.12-3.64], but it remained elevated without major fluctuations after longer time since hip fracture [HR (95% CI): 1.89 (1.50-2.37) after 1-4 years; 2.15 (1.81-2.55) after 4-8 years; 1.79 (1.57-2.05) after 8 or more years]. CONCLUSION: In this large population-based sample of older persons across eight cohorts, hip fracture was associated with excess short- and long-term all-cause mortality in both sexes.
BACKGROUND:Hip fractures are associated with diminished quality of life and survival especially amongst the elderly. OBJECTIVE: All-cause mortality after hip fracture was investigated to assess its magnitude. METHODS: A total of 122 808 participants from eight cohorts in Europe and the USA were followed up for a mean of 12.6 years, accumulating 4273 incident hip fractures and 27 999 deaths. Incident hip fractures were assessed through telephone interviews/questionnaires or national inpatient/fracture registries, and causes of death were verified with death certificates. Cox proportional hazards models and the time-dependent variable methodology were used to assess the association between hip fracture and mortality and its magnitude at different time intervals after the injury in each cohort. We obtained the effect estimates through a random-effects meta-analysis. RESULTS:Hip fracture was positively associated with increased all-cause mortality; the hazard ratio (HR) in the fully adjusted model was 2.12, 95% confidence interval (CI) 1.76-2.57, after adjusting for potential confounders. This association was stronger amongst men [HR: 2.39, 95% CI: 1.72-3.31] than amongst women [HR: 1.92, 95% CI: 1.54-2.39], although this difference was not significant. Mortality was higher during the first year after the hip fracture [HR: 2.78, 95% CI: 2.12-3.64], but it remained elevated without major fluctuations after longer time since hip fracture [HR (95% CI): 1.89 (1.50-2.37) after 1-4 years; 2.15 (1.81-2.55) after 4-8 years; 1.79 (1.57-2.05) after 8 or more years]. CONCLUSION: In this large population-based sample of older persons across eight cohorts, hip fracture was associated with excess short- and long-term all-cause mortality in both sexes.
Authors: Ken Iseri; Abdul Rashid Qureshi; Jonaz Ripsweden; Olof Heimbürger; Peter Barany; Ingrid B Bergström; Peter Stenvinkel; Torkel B Brismar; Bengt Lindholm Journal: J Bone Miner Metab Date: 2020-09-04 Impact factor: 2.626
Authors: Svetlana Ukraintseva; Konstantin Arbeev; Matt Duan; Igor Akushevich; Alexander Kulminski; Eric Stallard; Anatoliy Yashin Journal: Mech Ageing Dev Date: 2020-12-16 Impact factor: 5.432
Authors: Sherwood Dalton; Kathryn Smith; Kanwar Singh; Helen Kaiser; Ravindra Kolhe; Ashis K Mondal; Andrew Khayrullin; Carlos M Isales; Mark W Hamrick; William D Hill; Sadanand Fulzele Journal: Exp Gerontol Date: 2019-11-30 Impact factor: 4.032