Literature DB >> 28093234

The 1910HK/RR two-component system is essential for the virulence of Streptococcus suis serotype 2.

Fangyan Yuan1, Chen Tan2, Zewen Liu3, Keli Yang3, Danna Zhou3, Wei Liu3, Zhengying Duan3, Rui Guo3, Huanchun Chen2, Yongxiang Tian3, Weicheng Bei4.   

Abstract

Streptococcus suis serotype 2 is a major zoonotic pathogen, and the two-component system plays an important role in bacterial pathogenesis. The present study targeted the 1910HK/RR two-component system of S. suis 2. A 1910HK/RR deletion mutant (Δ1910HK/RR) and the corresponding complementation strain (CΔ1910HK/RR) were constructed in S. suis 2 strain 05ZYH33. 1910HK/RR deletion had no effect on S. suis 2 growth, but significantly inhibited the adherence and invasion of S. suis 2 to HEp-2 cells. Analysis of the role of 1910HK/RR in murine and pig infection models demonstrated that 1910HK/RR played a distinct role in the virulence of S. suis 2. In addition, deletion of 1910HK/RR significantly impaired the survival of 05ZYH33 in human blood. These data provided important insights into the pathogenesis of S. suis 2.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  1910HK/RR; Streptococcus suis; Two-component system; Virulence

Mesh：

Year:  2017        PMID： 28093234     DOI： 10.1016/j.micpath.2016.12.026

Source DB:  PubMed          Journal:  Microb Pathog        ISSN： 0882-4010            Impact factor:   3.738


  3 in total

1.  Identification of an Autorepressing Two-Component Signaling System That Modulates Virulence in Streptococcus suis Serotype 2.

Authors:  Xiaojun Zhong; Yue Zhang; Yinchu Zhu; Wenyang Dong; Jiale Ma; Zihao Pan; Huochun Yao
Journal:  Infect Immun       Date:  2019-08-21       Impact factor: 3.441

2.  The Two-Component Signaling System VraSRss Is Critical for Multidrug Resistance and Full Virulence in Streptococcus suis Serotype 2.

Authors:  Xiaojun Zhong; Yue Zhang; Yinchu Zhu; Wenyang Dong; Jiale Ma; Zihao Pan; Shipra Roy; Chengping Lu; Huochun Yao
Journal:  Infect Immun       Date:  2018-06-21       Impact factor: 3.441

3.  The VraSR regulatory system contributes to virulence in Streptococcus suis via resistance to innate immune defenses.

Authors:  Peixi Chang; Weitian Li; Guolin Shi; Huan Li; Xiaoqing Yang; Zechen Xia; Yuan Ren; Zhiwei Li; Huanchun Chen; Weicheng Bei
Journal:  Virulence       Date:  2018-12-31       Impact factor: 5.882
  3 in total

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