Bijan Movahedian Attar1, Navid Naghdi2, Milad Etemadi Sh3, Mojdeh Mehdizadeh4. 1. Associated Professor, Torabinejad Dental Research Center, Department of Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. 2. Postgraduate Student of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: 3n.navid.naghdi@gmail.com. 3. Assistant professor, Dental Implants Research Center, Department of Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. 4. Associate Professor, Torabinejad Dental Research Center, Department of Oral and Maxillofacial Radiology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Abstract
PURPOSE: Secondary grafting of alveolar defects with iliac crest bone is a common treatment method in cleft patients. The aim of this study was to evaluate the effectiveness of the combination of symphysis bone, allograft, and platelet-rich fibrin in regeneration of alveolar defects compared with iliac bone graft. MATERIALS AND METHODS: In this randomized clinical trial, patients with unilateral alveolar defects were divided randomly into two categories. Group A comprised patients in whom the combination of chin symphysis bone plus allogeneic bone material plus leukocyte- and platelet-rich fibrin was considered for treatment. Group B comprised patients in whom iliac bone graft was considered. Cone beam computed tomography before treatment and 1 year postoperatively was used for measurement of bone formation (bone volume in cubic centimeters). The data were analyzed by paired t and χ2 tests via SPSS software (version 23; IBM, Armonk, NY). P < .05 was considered significant. RESULTS: Each group included 10 patients (with 6 male patients in group A and 5 male patients in group B). The mean age of patients in groups A and B was 9.5 ± 1.5 years and 9.9 ± 1.9 years, respectively. The mean volume of alveolar defects was 0.89 ± 0.29 cm3 in group A and 0.95 ± 0.27 cm3 in group B. The percentage of bone regeneration in groups A and B was 69.5% and 73.8%, respectively. CONCLUSIONS: It seems that chin symphysis bone plus allogeneic bone material plus platelet-rich fibrin is a proper combination for bone regeneration in alveolar defects with a small to moderate volume range.
RCT Entities:
PURPOSE: Secondary grafting of alveolar defects with iliac crest bone is a common treatment method in cleftpatients. The aim of this study was to evaluate the effectiveness of the combination of symphysis bone, allograft, and platelet-rich fibrin in regeneration of alveolar defects compared with iliac bone graft. MATERIALS AND METHODS: In this randomized clinical trial, patients with unilateral alveolar defects were divided randomly into two categories. Group A comprised patients in whom the combination of chin symphysis bone plus allogeneic bone material plus leukocyte- and platelet-rich fibrin was considered for treatment. Group B comprised patients in whom iliac bone graft was considered. Cone beam computed tomography before treatment and 1 year postoperatively was used for measurement of bone formation (bone volume in cubic centimeters). The data were analyzed by paired t and χ2 tests via SPSS software (version 23; IBM, Armonk, NY). P < .05 was considered significant. RESULTS: Each group included 10 patients (with 6 male patients in group A and 5 male patients in group B). The mean age of patients in groups A and B was 9.5 ± 1.5 years and 9.9 ± 1.9 years, respectively. The mean volume of alveolar defects was 0.89 ± 0.29 cm3 in group A and 0.95 ± 0.27 cm3 in group B. The percentage of bone regeneration in groups A and B was 69.5% and 73.8%, respectively. CONCLUSIONS: It seems that chin symphysis bone plus allogeneic bone material plus platelet-rich fibrin is a proper combination for bone regeneration in alveolar defects with a small to moderate volume range.