Xuelian Cui1, Wei Niu2, Lingming Kong3, Mingjun He3, Kunhong Jiang3, Shengdong Chen4, Aifang Zhong5, Qiaoli Zhang6, Wanshuai Li7, Jim Lu7,8, Liyi Zhang3. 1. Department of Health Care, Changzhou Maternity & Child Health Care Hospital Affiliated with Nanjing Medical University, Changzhou, People's Republic of China. 2. Department of Rehabilitation, No. 102 Hospital of the Chinese People's Liberation Army, Changzhou, People's Republic of China. 3. Prevention & Treatment Center for Psychological Diseases, No. 102 Hospital of the Chinese People's Liberation Army, Changzhou, People's Republic of China. 4. Department of Neurology, No. 102 Hospital of the Chinese People's Liberation Army, Changzhou, People's Republic of China. 5. Clinical Laboratory, No. 102 Hospital of the Chinese People's Liberation Army, Changzhou, People's Republic of China. 6. Department of Special Ward, The First People's Hospital of Changzhou, Changzhou, People's Republic of China. 7. Gopath Diagnostic Laboratory Co. Ltd, No. 801, Changzhou, People's Republic of China. 8. Gopath Laboratories LLC, 1351 Barclay Blvd, Buffalo Grove, IL 60089, USA.
Abstract
AIM: Depression and anxiety are common symptoms for schizophrenia (SZ) in the early onset. This study aimed to determine whether long noncoding RNAs (lncRNAs) can be indicators for diagnosing SZ in nonpsychiatric hospitals. MATERIALS & METHODS: Three upregulated SZ lncRNAs, six downregulated major depressive disorder (MDD) lncRNAs and three upregulated generalized anxiety disorder (GAD) lncRNAs were cross-validated in 45 SZ patients, 48 MDD patients, 52 GAD patients and 40 controls by reverse transcription-PCR. RESULTS: Three SZ lncRNAs were significantly downregulated in GAD patients. The expression of the six MDD lncRNAs showed an opposite trend in SZ patients, and the three GAD lncRNAs also showed significant differences between SZ and GAD patients. CONCLUSION: The three upregulated SZ lncRNAs are not entirely replicated in MDD and GAD patients and could be potential indicators for distinguishing SZ from MDD and GAD in nonpsychiatric hospital.
AIM: Depression and anxiety are common symptoms for schizophrenia (SZ) in the early onset. This study aimed to determine whether long noncoding RNAs (lncRNAs) can be indicators for diagnosing SZ in nonpsychiatric hospitals. MATERIALS & METHODS: Three upregulated SZ lncRNAs, six downregulated major depressive disorder (MDD) lncRNAs and three upregulated generalized anxiety disorder (GAD) lncRNAs were cross-validated in 45 SZ patients, 48 MDDpatients, 52 GAD patients and 40 controls by reverse transcription-PCR. RESULTS: Three SZ lncRNAs were significantly downregulated in GAD patients. The expression of the six MDD lncRNAs showed an opposite trend in SZ patients, and the three GAD lncRNAs also showed significant differences between SZ and GAD patients. CONCLUSION: The three upregulated SZ lncRNAs are not entirely replicated in MDD and GAD patients and could be potential indicators for distinguishing SZ from MDD and GAD in nonpsychiatric hospital.
Authors: Gabriel A Cipolla; Jaqueline C de Oliveira; Amanda Salviano-Silva; Sara C Lobo-Alves; Debora S Lemos; Luana C Oliveira; Tayana S Jucoski; Carolina Mathias; Gabrielle A Pedroso; Erika P Zambalde; Daniela F Gradia Journal: Noncoding RNA Date: 2018-05-11
Authors: Piotr Czarny; Katarzyna Białek; Sylwia Ziółkowska; Justyna Strycharz; Gabriela Barszczewska; Tomasz Sliwinski Journal: J Pers Med Date: 2021-03-01