| Literature DB >> 28092125 |
Sukeun Kuk1, Byung Il Lee1, Joon Seok Lee1, Chan Beum Park1.
Abstract
Rose bengal (RB)-loaded upconverting nanocomposites are synthesized as a near-infrared (NIR)-responsive inhibitor of Aβ aggregation. Rattle-structured, organosilica shell (ROS) is deposited on NaYF4 :Yb,Er nanocrystals (UCNPs) for high loading efficiency and disaggregation of RB. RB/UCNP@ROS successfully inhibits Aβ self-assembly under NIR irradiation by generating 1 O2 . Furthermore, photoexcited RB/UCNP@ROS is effective in suppressing Aβ-induced cytotoxicity.Entities:
Keywords: near-infrared light; photosensitizers; self-assembly; upconversion nanoparticles; β-amyloid
Mesh：
Substances：
Year: 2017 PMID： 28092125 DOI： 10.1002/smll.201603139
Source DB: PubMed Journal: Small ISSN： 1613-6810 Impact factor: 13.281