Sana Ansari1,2, Mickey Karram3,4. 1. Division of Female Pelvic Medicine and Reconstructive Surgery, University of Cincinnati, Cincinnati, OH, USA. sana.hussain@thechristhospital.com. 2. Women's Health Service Line, Urogynecology and Pelvic Floor Medicine, The Christ Hospital, 2123 Auburn Ave, MOB 307, Cincinnati, OH, 45219, USA. sana.hussain@thechristhospital.com. 3. Division of Female Pelvic Medicine and Reconstructive Surgery, University of Cincinnati, Cincinnati, OH, USA. 4. Women's Health Service Line, Urogynecology and Pelvic Floor Medicine, The Christ Hospital, 2123 Auburn Ave, MOB 307, Cincinnati, OH, 45219, USA.
Abstract
INTRODUCTION AND HYPOTHESIS: Female urethral reconstruction via the traditional routes can be limiting for various reasons. Current literature on the use of acellular biologic grafts derived from viscera for female urethral reconstruction is limited. We present two cases of women with complete loss of their posterior urethra presenting for urethral reconstruction. METHODS: Two cases of urethral reconstruction using acellular porcine urinary bladder matrix (UBM), along with labial fat pad transposition and biologic pubovaginal sling are presented. RESULTS: In both cases the UBM graft showed successful conversion to what appeared to be normal urethral mucosa. One woman showed significant improvement in continence and the other showed complete continence. CONCLUSIONS: Female urethral reconstruction using acellular porcine UBM is a viable option for patients who have lost a significant portion of their urethra. Both cases demonstrated transition of the graft into the posterior wall of the urethra with significant improvement in continence. Further studies are needed to confirm that acellular porcine UBM can transform to urethral mucosa in women requiring urethral reconstruction.
INTRODUCTION AND HYPOTHESIS: Female urethral reconstruction via the traditional routes can be limiting for various reasons. Current literature on the use of acellular biologic grafts derived from viscera for female urethral reconstruction is limited. We present two cases of women with complete loss of their posterior urethra presenting for urethral reconstruction. METHODS: Two cases of urethral reconstruction using acellular porcine urinary bladder matrix (UBM), along with labial fat pad transposition and biologic pubovaginal sling are presented. RESULTS: In both cases the UBM graft showed successful conversion to what appeared to be normal urethral mucosa. One woman showed significant improvement in continence and the other showed complete continence. CONCLUSIONS: Female urethral reconstruction using acellular porcine UBM is a viable option for patients who have lost a significant portion of their urethra. Both cases demonstrated transition of the graft into the posterior wall of the urethra with significant improvement in continence. Further studies are needed to confirm that acellular porcine UBM can transform to urethral mucosa in women requiring urethral reconstruction.
Authors: Brian M Sicari; J Peter Rubin; Christopher L Dearth; Matthew T Wolf; Fabrisia Ambrosio; Michael Boninger; Neill J Turner; Douglas J Weber; Tyler W Simpson; Aaron Wyse; Elke H P Brown; Jenna L Dziki; Lee E Fisher; Spencer Brown; Stephen F Badylak Journal: Sci Transl Med Date: 2014-04-30 Impact factor: 17.956
Authors: Kevin J Chua; Mark Mikhail; Hiren V Patel; Alexandra L Tabakin; Sai Krishnaraya Doppalapudi; Joshua Sterling; Hari Sgr Tunuguntla Journal: Res Rep Urol Date: 2021-06-21