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Literature DB >> 28090578

A phenotypic and mechanistic perspective on heterogeneity of HER2-positive breast cancers.

Anthony Ferrari¹, Anne-Sophie Sertier¹, Anne Vincent-Salomon², Xavier Pivot³, Iris Pauporté⁴, Pierre Saintigny⁵, Daniel Birnbaum⁶, Alain Viari⁷.

Abstract

Analysis of gene expression and whole-genome features of 64 human epidermal growth factor 2 (HER2)-positive breast tumors supports the idea that their intrinsic heterogeneity actually reflects their cell of origin, suggesting that HER2 amplification is an embedded event in the natural history of these tumors. Possible mechanisms for this event involve breakage-fusion-bridge and chromothripsis.

Entities: Disease Gene Species

Keywords: Breakage-Fusion-Bridge; Breast cancer; ERBB2 amplification; cancer genomics; mammary epithelial hierarchy

Year: 2016 PMID： 28090578 PMCID： PMC5160388 DOI： 10.1080/23723556.2016.1232186

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

10 in total

1. Immune modulation of pathologic complete response after neoadjuvant HER2-directed therapies in the NeoSphere trial.

Authors: G Bianchini; L Pusztai; T Pienkowski; Y-H Im; G V Bianchi; L-M Tseng; M-C Liu; A Lluch; E Galeota; D Magazzù; J de la Haba-Rodríguez; D-Y Oh; B Poirier; J L Pedrini; V Semiglazov; P Valagussa; L Gianni
Journal: Ann Oncol Date: 2015-09-19 Impact factor: 32.976

2. Novel patterns of genome rearrangement and their association with survival in breast cancer.

Authors: James Hicks; Alexander Krasnitz; B Lakshmi; Nicholas E Navin; Michael Riggs; Evan Leibu; Diane Esposito; Joan Alexander; Jen Troge; Vladimir Grubor; Seungtai Yoon; Michael Wigler; Kenny Ye; Anne-Lise Børresen-Dale; Bjørn Naume; Ellen Schlicting; Larry Norton; Torsten Hägerström; Lambert Skoog; Gert Auer; Susanne Månér; Pär Lundin; Anders Zetterberg
Journal: Genome Res Date: 2006-12 Impact factor: 9.043

Review 3. The origin of breast tumor heterogeneity.

Authors: A Skibinski; C Kuperwasser
Journal: Oncogene Date: 2015-02-23 Impact factor: 9.867

4. Adjuvant trastuzumab in HER2-positive breast cancer.

Authors: Dennis Slamon; Wolfgang Eiermann; Nicholas Robert; Tadeusz Pienkowski; Miguel Martin; Michael Press; John Mackey; John Glaspy; Arlene Chan; Marek Pawlicki; Tamas Pinter; Vicente Valero; Mei-Ching Liu; Guido Sauter; Gunter von Minckwitz; Frances Visco; Valerie Bee; Marc Buyse; Belguendouz Bendahmane; Isabelle Tabah-Fisch; Mary-Ann Lindsay; Alessandro Riva; John Crown
Journal: N Engl J Med Date: 2011-10-06 Impact factor: 91.245

5. High-resolution genomic and expression analyses of copy number alterations in HER2-amplified breast cancer.

Authors: Johan Staaf; Göran Jönsson; Markus Ringnér; Johan Vallon-Christersson; Dorthe Grabau; Adalgeir Arason; Haukur Gunnarsson; Bjarni A Agnarsson; Per-Olof Malmström; Oskar Th Johannsson; Niklas Loman; Rosa B Barkardottir; Ake Borg
Journal: Breast Cancer Res Date: 2010-05-06 Impact factor: 6.466

6. Molecular Heterogeneity and Response to Neoadjuvant Human Epidermal Growth Factor Receptor 2 Targeting in CALGB 40601, a Randomized Phase III Trial of Paclitaxel Plus Trastuzumab With or Without Lapatinib.

Authors: Lisa A Carey; Donald A Berry; Constance T Cirrincione; William T Barry; Brandelyn N Pitcher; Lyndsay N Harris; David W Ollila; Ian E Krop; Norah Lynn Henry; Douglas J Weckstein; Carey K Anders; Baljit Singh; Katherine A Hoadley; Michael Iglesia; Maggie Chon U Cheang; Charles M Perou; Eric P Winer; Clifford A Hudis
Journal: J Clin Oncol Date: 2015-11-02 Impact factor: 44.544

7. Estimation of rearrangement phylogeny for cancer genomes.

Authors: Chris D Greenman; Erin D Pleasance; Scott Newman; Fengtang Yang; Beiyuan Fu; Serena Nik-Zainal; David Jones; King Wai Lau; Nigel Carter; Paul A W Edwards; P Andrew Futreal; Michael R Stratton; Peter J Campbell
Journal: Genome Res Date: 2011-10-12 Impact factor: 9.043

Review 8. Mammary stem cells and the differentiation hierarchy: current status and perspectives.

Authors: Jane E Visvader; John Stingl
Journal: Genes Dev Date: 2014-06-01 Impact factor: 11.361

9. Molecular features and survival outcomes of the intrinsic subtypes within HER2-positive breast cancer.

Authors: Aleix Prat; Lisa A Carey; Barbara Adamo; Maria Vidal; Josep Tabernero; Javier Cortés; Joel S Parker; Charles M Perou; José Baselga
Journal: J Natl Cancer Inst Date: 2014-08-19 Impact factor: 13.506

10. A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers.

Authors: Anthony Ferrari; Anne Vincent-Salomon; Xavier Pivot; Anne-Sophie Sertier; Emilie Thomas; Laurie Tonon; Sandrine Boyault; Eskeatnaf Mulugeta; Isabelle Treilleux; Gaëtan MacGrogan; Laurent Arnould; Janice Kielbassa; Vincent Le Texier; Hélène Blanché; Jean-François Deleuze; Jocelyne Jacquemier; Marie-Christine Mathieu; Frédérique Penault-Llorca; Frédéric Bibeau; Odette Mariani; Cécile Mannina; Jean-Yves Pierga; Olivier Trédan; Thomas Bachelot; Hervé Bonnefoi; Gilles Romieu; Pierre Fumoleau; Suzette Delaloge; Maria Rios; Jean-Marc Ferrero; Carole Tarpin; Catherine Bouteille; Fabien Calvo; Ivo Glynne Gut; Marta Gut; Sancha Martin; Serena Nik-Zainal; Michael R Stratton; Iris Pauporté; Pierre Saintigny; Daniel Birnbaum; Alain Viari; Gilles Thomas
Journal: Nat Commun Date: 2016-07-13 Impact factor: 14.919