Literature DB >> 28090577

Modeling intratumor heterogeneity through CRISPR-barcodes.

Alexis Guernet1, Stuart A Aaronson2, Youssef Anouar1, Luca Grumolato1.   

Abstract

We have devised a barcoding strategy to recapitulate cancer evolution through the emergence of subclonal mutations of interest, whose effects can be monitored in a dynamic manner. This approach can be easily adapted for a variety of applications, including combined modeling of multiple mechanisms of drug resistance or repair of oncogenic driver mutations in addicted cancer cells.

Entities:  

Keywords:  ALK; APC; CRISPR/Cas9; EGFR; TP53; genetic barcoding; non-small cell lung cancer; resistance; tumor heterogeneity

Year:  2016        PMID： 28090577      PMCID： PMC5160400          DOI： 10.1080/23723556.2016.1227894

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Genome editing. The new frontier of genome engineering with CRISPR-Cas9.

Authors:  Jennifer A Doudna; Emmanuelle Charpentier
Journal:  Science       Date:  2014-11-28       Impact factor: 47.728

2.  Studying clonal dynamics in response to cancer therapy using high-complexity barcoding.

Authors:  Hyo-eun C Bhang; David A Ruddy; Viveksagar Krishnamurthy Radhakrishna; Justina X Caushi; Rui Zhao; Matthew M Hims; Angad P Singh; Iris Kao; Daniel Rakiec; Pamela Shaw; Marissa Balak; Alina Raza; Elizabeth Ackley; Nicholas Keen; Michael R Schlabach; Michael Palmer; Rebecca J Leary; Derek Y Chiang; William R Sellers; Franziska Michor; Vesselina G Cooke; Joshua M Korn; Frank Stegmeier
Journal:  Nat Med       Date:  2015-04-13       Impact factor: 53.440

3.  Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease.

Authors:  Cem Kuscu; Sevki Arslan; Ritambhara Singh; Jeremy Thorpe; Mazhar Adli
Journal:  Nat Biotechnol       Date:  2014-05-18       Impact factor: 54.908

Review 4.  Development and applications of CRISPR-Cas9 for genome engineering.

Authors:  Patrick D Hsu; Eric S Lander; Feng Zhang
Journal:  Cell       Date:  2014-06-05       Impact factor: 41.582

Review 5.  Biological and therapeutic impact of intratumor heterogeneity in cancer evolution.

Authors:  Nicholas McGranahan; Charles Swanton
Journal:  Cancer Cell       Date:  2015-01-12       Impact factor: 31.743

6.  Genome engineering using the CRISPR-Cas9 system.

Authors:  F Ann Ran; Patrick D Hsu; Jason Wright; Vineeta Agarwala; David A Scott; Feng Zhang
Journal:  Nat Protoc       Date:  2013-10-24       Impact factor: 13.491

7.  Tumor heterogeneity confounds and illuminates: assessing the implications.

Authors:  Maria Kleppe; Ross L Levine
Journal:  Nat Med       Date:  2014-04       Impact factor: 53.440

8.  CRISPR-Barcoding for Intratumor Genetic Heterogeneity Modeling and Functional Analysis of Oncogenic Driver Mutations.

Authors:  Alexis Guernet; Sathish Kumar Mungamuri; Dorthe Cartier; Ravi Sachidanandam; Anitha Jayaprakash; Sahil Adriouch; Myriam Vezain; Françoise Charbonnier; Guy Rohkin; Sophie Coutant; Shen Yao; Hassan Ainani; David Alexandre; Isabelle Tournier; Olivier Boyer; Stuart A Aaronson; Youssef Anouar; Luca Grumolato
Journal:  Mol Cell       Date:  2016-07-21       Impact factor: 17.970

9.  Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells.

Authors:  Long V Nguyen; Davide Pellacani; Sylvain Lefort; Nagarajan Kannan; Tomo Osako; Maisam Makarem; Claire L Cox; William Kennedy; Philip Beer; Annaick Carles; Michelle Moksa; Misha Bilenky; Sneha Balani; Sonja Babovic; Ivan Sun; Miriam Rosin; Samuel Aparicio; Martin Hirst; Connie J Eaves
Journal:  Nature       Date:  2015-12-02       Impact factor: 49.962

10.  High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells.

Authors:  Yanfang Fu; Jennifer A Foden; Cyd Khayter; Morgan L Maeder; Deepak Reyon; J Keith Joung; Jeffry D Sander
Journal:  Nat Biotechnol       Date:  2013-06-23       Impact factor: 54.908
  10 in total
  2 in total

1.  Applications of CRISPR/Cas technology against drug-resistant lung cancers: an update.

Authors:  Mayank Chaudhary; Pooja Sharma; Tapan Kumar Mukherjee
Journal:  Mol Biol Rep       Date:  2022-09-12       Impact factor: 2.742

2.  Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells.

Authors:  Kefeng Lei; Ran Sun; Lee H Chen; Bill H Diplas; Casey J Moure; Wenzhe Wang; Landon J Hansen; Yulei Tao; Xufeng Chen; Chin-Pu Jason Chen; Paula K Greer; Fangping Zhao; Hai Yan; Darell D Bigner; Jiaoti Huang; Yiping He
Journal:  Sci Rep       Date:  2018-08-21       Impact factor: 4.379
  2 in total

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