Literature DB >> 28090576

Cancer cells activate damage-tolerant and error-prone DNA synthesis.

Elizabeth Mutter-Rottmayer1, Yanzhe Gao2, Cyrus Vaziri2.   

Abstract

Trans-lesion synthesis (TLS) is a DNA damage-tolerant and error-prone mode of DNA replication. Recent work shows that many cancer cells coopt an aberrantly expressed germ cell protein, melanoma antigen-A4 (MAGE-A4), to activate TLS. MAGE-A4-induced "pathological TLS" provides a potential mechanism through which neoplastic cells can tolerate intrinsic and therapeutic genotoxicity while acquiring mutability.

Entities:  

Keywords:  Cancer-testes antigens (CTA); DNA damage; RAD18; genome maintenance; melanoma antigen-A4 (MAGE-A4); mutagenesis; trans-lesion synthesis (TLS)

Year:  2016        PMID： 28090576      PMCID： PMC5160398          DOI： 10.1080/23723556.2016.1225547

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function.

Authors:  Satya Prakash; Robert E Johnson; Louise Prakash
Journal:  Annu Rev Biochem       Date:  2005       Impact factor: 23.643

2.  The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta.

Authors:  C Masutani; R Kusumoto; A Yamada; N Dohmae; M Yokoi; M Yuasa; M Araki; S Iwai; K Takio; F Hanaoka
Journal:  Nature       Date:  1999-06-17       Impact factor: 49.962

3.  Oncogenic MAGEA-TRIM28 ubiquitin ligase downregulates autophagy by ubiquitinating and degrading AMPK in cancer.

Authors:  Carlos T Pineda; Patrick Ryan Potts
Journal:  Autophagy       Date:  2015       Impact factor: 16.016

4.  MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.

Authors:  Jennifer M Doyle; Jinlan Gao; Jiawei Wang; Maojun Yang; Patrick Ryan Potts
Journal:  Mol Cell       Date:  2010-09-24       Impact factor: 17.970

Review 5.  Regulation of Rad6/Rad18 Activity During DNA Damage Tolerance.

Authors:  Mark Hedglin; Stephen J Benkovic
Journal:  Annu Rev Biophys       Date:  2015       Impact factor: 12.981

6.  Degradation of AMPK by a cancer-specific ubiquitin ligase.

Authors:  Carlos T Pineda; Saumya Ramanathan; Klementina Fon Tacer; Jenny L Weon; Malia B Potts; Yi-Hung Ou; Michael A White; Patrick Ryan Potts
Journal:  Cell       Date:  2015-02-12       Impact factor: 41.582

Review 7.  Cancer/testis antigens, gametogenesis and cancer.

Authors:  Andrew J G Simpson; Otavia L Caballero; Achim Jungbluth; Yao-Tseng Chen; Lloyd J Old
Journal:  Nat Rev Cancer       Date:  2005-08       Impact factor: 60.716

Review 8.  The MAGE protein family and cancer.

Authors:  Jenny L Weon; Patrick Ryan Potts
Journal:  Curr Opin Cell Biol       Date:  2015-09-03       Impact factor: 8.382

Review 9.  Hallmarks of cancer: the next generation.

Authors:  Douglas Hanahan; Robert A Weinberg
Journal:  Cell       Date:  2011-03-04       Impact factor: 41.582

10.  A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.

Authors:  Yanzhe Gao; Elizabeth Mutter-Rottmayer; Alicia M Greenwalt; Dennis Goldfarb; Feng Yan; Yang Yang; Raquel C Martinez-Chacin; Kenneth H Pearce; Satoshi Tateishi; Michael B Major; Cyrus Vaziri
Journal:  Nat Commun       Date:  2016-07-05       Impact factor: 14.919
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.