Literature DB >> 28090572

Pleiotrophin is a driver of vascular abnormalization in glioblastoma.

Lei Zhang1, Anna Dimberg1.   

Abstract

In a recent report by Zhang et al., pleiotrophin (PTN) was demonstrated to enhance glioma growth by promoting vascular abnormalization. PTN stimulates glioma vessels through anaplastic lymphoma kinase (Alk)-mediated perivascular deposition of vascular endothelial growth factor (VEGF). Targeting of Alk or VEGF signaling normalizes tumor vessels in PTN-expressing tumors.

Entities:  

Keywords:  ALK; GL261; VEGF; glioblastoma; pleiotrophin; vascular abnormalization

Year:  2016        PMID： 28090572      PMCID： PMC5160416          DOI： 10.1080/23723556.2016.1141087

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  The glioblastoma vasculature as a target for cancer therapy.

Authors:  Anna Dimberg
Journal:  Biochem Soc Trans       Date:  2014-12       Impact factor: 5.407

2.  The somatic genomic landscape of glioblastoma.

Authors:  Cameron W Brennan; Roel G W Verhaak; Aaron McKenna; Benito Campos; Houtan Noushmehr; Sofie R Salama; Siyuan Zheng; Debyani Chakravarty; J Zachary Sanborn; Samuel H Berman; Rameen Beroukhim; Brady Bernard; Chang-Jiun Wu; Giannicola Genovese; Ilya Shmulevich; Jill Barnholtz-Sloan; Lihua Zou; Rahulsimham Vegesna; Sachet A Shukla; Giovanni Ciriello; W K Yung; Wei Zhang; Carrie Sougnez; Tom Mikkelsen; Kenneth Aldape; Darell D Bigner; Erwin G Van Meir; Michael Prados; Andrew Sloan; Keith L Black; Jennifer Eschbacher; Gaetano Finocchiaro; William Friedman; David W Andrews; Abhijit Guha; Mary Iacocca; Brian P O'Neill; Greg Foltz; Jerome Myers; Daniel J Weisenberger; Robert Penny; Raju Kucherlapati; Charles M Perou; D Neil Hayes; Richard Gibbs; Marco Marra; Gordon B Mills; Eric Lander; Paul Spellman; Richard Wilson; Chris Sander; John Weinstein; Matthew Meyerson; Stacey Gabriel; Peter W Laird; David Haussler; Gad Getz; Lynda Chin
Journal:  Cell       Date:  2013-10-10       Impact factor: 41.582

3.  Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

Authors:  Daniel J Brat; Roel G W Verhaak; Kenneth D Aldape; W K Alfred Yung; Sofie R Salama; Lee A D Cooper; Esther Rheinbay; C Ryan Miller; Mark Vitucci; Olena Morozova; A Gordon Robertson; Houtan Noushmehr; Peter W Laird; Andrew D Cherniack; Rehan Akbani; Jason T Huse; Giovanni Ciriello; Laila M Poisson; Jill S Barnholtz-Sloan; Mitchel S Berger; Cameron Brennan; Rivka R Colen; Howard Colman; Adam E Flanders; Caterina Giannini; Mia Grifford; Antonio Iavarone; Rajan Jain; Isaac Joseph; Jaegil Kim; Katayoon Kasaian; Tom Mikkelsen; Bradley A Murray; Brian Patrick O'Neill; Lior Pachter; Donald W Parsons; Carrie Sougnez; Erik P Sulman; Scott R Vandenberg; Erwin G Van Meir; Andreas von Deimling; Hailei Zhang; Daniel Crain; Kevin Lau; David Mallery; Scott Morris; Joseph Paulauskis; Robert Penny; Troy Shelton; Mark Sherman; Peggy Yena; Aaron Black; Jay Bowen; Katie Dicostanzo; Julie Gastier-Foster; Kristen M Leraas; Tara M Lichtenberg; Christopher R Pierson; Nilsa C Ramirez; Cynthia Taylor; Stephanie Weaver; Lisa Wise; Erik Zmuda; Tanja Davidsen; John A Demchok; Greg Eley; Martin L Ferguson; Carolyn M Hutter; Kenna R Mills Shaw; Bradley A Ozenberger; Margi Sheth; Heidi J Sofia; Roy Tarnuzzer; Zhining Wang; Liming Yang; Jean Claude Zenklusen; Brenda Ayala; Julien Baboud; Sudha Chudamani; Mark A Jensen; Jia Liu; Todd Pihl; Rohini Raman; Yunhu Wan; Ye Wu; Adrian Ally; J Todd Auman; Miruna Balasundaram; Saianand Balu; Stephen B Baylin; Rameen Beroukhim; Moiz S Bootwalla; Reanne Bowlby; Christopher A Bristow; Denise Brooks; Yaron Butterfield; Rebecca Carlsen; Scott Carter; Lynda Chin; Andy Chu; Eric Chuah; Kristian Cibulskis; Amanda Clarke; Simon G Coetzee; Noreen Dhalla; Tim Fennell; Sheila Fisher; Stacey Gabriel; Gad Getz; Richard Gibbs; Ranabir Guin; Angela Hadjipanayis; D Neil Hayes; Toshinori Hinoue; Katherine Hoadley; Robert A Holt; Alan P Hoyle; Stuart R Jefferys; Steven Jones; Corbin D Jones; Raju Kucherlapati; Phillip H Lai; Eric Lander; Semin Lee; Lee Lichtenstein; Yussanne Ma; Dennis T Maglinte; Harshad S Mahadeshwar; Marco A Marra; Michael Mayo; Shaowu Meng; Matthew L Meyerson; Piotr A Mieczkowski; Richard A Moore; Lisle E Mose; Andrew J Mungall; Angeliki Pantazi; Michael Parfenov; Peter J Park; Joel S Parker; Charles M Perou; Alexei Protopopov; Xiaojia Ren; Jeffrey Roach; Thaís S Sabedot; Jacqueline Schein; Steven E Schumacher; Jonathan G Seidman; Sahil Seth; Hui Shen; Janae V Simons; Payal Sipahimalani; Matthew G Soloway; Xingzhi Song; Huandong Sun; Barbara Tabak; Angela Tam; Donghui Tan; Jiabin Tang; Nina Thiessen; Timothy Triche; David J Van Den Berg; Umadevi Veluvolu; Scot Waring; Daniel J Weisenberger; Matthew D Wilkerson; Tina Wong; Junyuan Wu; Liu Xi; Andrew W Xu; Lixing Yang; Travis I Zack; Jianhua Zhang; B Arman Aksoy; Harindra Arachchi; Chris Benz; Brady Bernard; Daniel Carlin; Juok Cho; Daniel DiCara; Scott Frazer; Gregory N Fuller; JianJiong Gao; Nils Gehlenborg; David Haussler; David I Heiman; Lisa Iype; Anders Jacobsen; Zhenlin Ju; Sol Katzman; Hoon Kim; Theo Knijnenburg; Richard Bailey Kreisberg; Michael S Lawrence; William Lee; Kalle Leinonen; Pei Lin; Shiyun Ling; Wenbin Liu; Yingchun Liu; Yuexin Liu; Yiling Lu; Gordon Mills; Sam Ng; Michael S Noble; Evan Paull; Arvind Rao; Sheila Reynolds; Gordon Saksena; Zack Sanborn; Chris Sander; Nikolaus Schultz; Yasin Senbabaoglu; Ronglai Shen; Ilya Shmulevich; Rileen Sinha; Josh Stuart; S Onur Sumer; Yichao Sun; Natalie Tasman; Barry S Taylor; Doug Voet; Nils Weinhold; John N Weinstein; Da Yang; Kosuke Yoshihara; Siyuan Zheng; Wei Zhang; Lihua Zou; Ty Abel; Sara Sadeghi; Mark L Cohen; Jenny Eschbacher; Eyas M Hattab; Aditya Raghunathan; Matthew J Schniederjan; Dina Aziz; Gene Barnett; Wendi Barrett; Darell D Bigner; Lori Boice; Cathy Brewer; Chiara Calatozzolo; Benito Campos; Carlos Gilberto Carlotti; Timothy A Chan; Lucia Cuppini; Erin Curley; Stefania Cuzzubbo; Karen Devine; Francesco DiMeco; Rebecca Duell; J Bradley Elder; Ashley Fehrenbach; Gaetano Finocchiaro; William Friedman; Jordonna Fulop; Johanna Gardner; Beth Hermes; Christel Herold-Mende; Christine Jungk; Ady Kendler; Norman L Lehman; Eric Lipp; Ouida Liu; Randy Mandt; Mary McGraw; Roger Mclendon; Christopher McPherson; Luciano Neder; Phuong Nguyen; Ardene Noss; Raffaele Nunziata; Quinn T Ostrom; Cheryl Palmer; Alessandro Perin; Bianca Pollo; Alexander Potapov; Olga Potapova; W Kimryn Rathmell; Daniil Rotin; Lisa Scarpace; Cathy Schilero; Kelly Senecal; Kristen Shimmel; Vsevolod Shurkhay; Suzanne Sifri; Rosy Singh; Andrew E Sloan; Kathy Smolenski; Susan M Staugaitis; Ruth Steele; Leigh Thorne; Daniela P C Tirapelli; Andreas Unterberg; Mahitha Vallurupalli; Yun Wang; Ronald Warnick; Felicia Williams; Yingli Wolinsky; Sue Bell; Mara Rosenberg; Chip Stewart; Franklin Huang; Jonna L Grimsby; Amie J Radenbaugh; Jianan Zhang
Journal:  N Engl J Med       Date:  2015-06-10       Impact factor: 91.245

4.  Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization.

Authors:  Lothar C Dieterich; Sofie Mellberg; Elise Langenkamp; Lei Zhang; Agata Zieba; Henriikka Salomäki; Martin Teichert; Hua Huang; Per-Henrik Edqvist; Theo Kraus; Hellmut G Augustin; Tommie Olofsson; Erik Larsson; Ola Söderberg; Grietje Molema; Fredrik Pontén; Patrik Georgii-Hemming; Irina Alafuzoff; Anna Dimberg
Journal:  J Pathol       Date:  2012-08-31       Impact factor: 7.996

5.  Lessons from anti-vascular endothelial growth factor and anti-vascular endothelial growth factor receptor trials in patients with glioblastoma.

Authors:  Christine Lu-Emerson; Dan G Duda; Kyrre E Emblem; Jennie W Taylor; Elizabeth R Gerstner; Jay S Loeffler; Tracy T Batchelor; Rakesh K Jain
Journal:  J Clin Oncol       Date:  2015-02-23       Impact factor: 44.544

6.  Ribozyme-targeting reveals the rate-limiting role of pleiotrophin in glioblastoma.

Authors:  Marius Grzelinski; Nicole Bader; Frank Czubayko; Achim Aigner
Journal:  Int J Cancer       Date:  2005-12-20       Impact factor: 7.396

7.  Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation.

Authors:  Tracy T Batchelor; Elizabeth R Gerstner; Kyrre E Emblem; Dan G Duda; Jayashree Kalpathy-Cramer; Matija Snuderl; Marek Ancukiewicz; Pavlina Polaskova; Marco C Pinho; Dominique Jennings; Scott R Plotkin; Andrew S Chi; April F Eichler; Jorg Dietrich; Fred H Hochberg; Christine Lu-Emerson; A John Iafrate; S Percy Ivy; Bruce R Rosen; Jay S Loeffler; Patrick Y Wen; A Greg Sorensen; Rakesh K Jain
Journal:  Proc Natl Acad Sci U S A       Date:  2013-11-04       Impact factor: 11.205

8.  Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.

Authors:  Lei Zhang; Soumi Kundu; Tjerk Feenstra; Xiujuan Li; Chuan Jin; Liisi Laaniste; Tamador Elsir Abu El Hassan; K Elisabet Ohlin; Di Yu; Tommie Olofsson; Anna-Karin Olsson; Fredrik Pontén; Peetra U Magnusson; Karin Forsberg Nilsson; Magnus Essand; Anja Smits; Lothar C Dieterich; Anna Dimberg
Journal:  Sci Signal       Date:  2015-12-08       Impact factor: 8.192

Review 9.  Pleiotrophin, a multifunctional angiogenic factor: mechanisms and pathways in normal and pathological angiogenesis.

Authors:  Pablo Perez-Pinera; James R Berenson; Thomas F Deuel
Journal:  Curr Opin Hematol       Date:  2008-05       Impact factor: 3.284

Review 10.  The 2007 WHO classification of tumours of the central nervous system.

Authors:  David N Louis; Hiroko Ohgaki; Otmar D Wiestler; Webster K Cavenee; Peter C Burger; Anne Jouvet; Bernd W Scheithauer; Paul Kleihues
Journal:  Acta Neuropathol       Date:  2007-07-06       Impact factor: 17.088
  10 in total
  6 in total

1.  Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex.

Authors:  John C van Swieten; Bart J L Eggen; Emma Gerrits; Lucia A A Giannini; Nieske Brouwer; Shamiram Melhem; Danielle Seilhean; Isabelle Le Ber; Alwin Kamermans; Gijs Kooij; Helga E de Vries; Erik W G M Boddeke; Harro Seelaar
Journal:  Nat Neurosci       Date:  2022-07-25       Impact factor: 28.771

Review 2.  A systematic review and meta-analysis on the differentiation of glioma grade and mutational status by use of perfusion-based magnetic resonance imaging.

Authors:  Lusien van Santwijk; Valentina Kouwenberg; Frederick Meijer; Marion Smits; Dylan Henssen
Journal:  Insights Imaging       Date:  2022-06-07

3.  Genome-wide screening identifies oncofetal lncRNA Ptn-dt promoting the proliferation of hepatocellular carcinoma cells by regulating the Ptn receptor.

Authors:  Jin-Feng Huang; Hong-Yue Jiang; Hui Cai; Yan Liu; Yi-Qing Zhu; Sha-Sha Lin; Ting-Ting Hu; Tian-Tian Wang; Wen-Jun Yang; Bang Xiao; Shu-Han Sun; Li-Ye Ma; Hui-Rong Yin; Fang Wang
Journal:  Oncogene       Date:  2019-01-14       Impact factor: 9.867

4.  ALK signaling cascade confers multiple advantages to glioblastoma cells through neovascularization and cell proliferation.

Authors:  Risako Chiba; Masashi Akiya; Miki Hashimura; Yasuko Oguri; Madoka Inukai; Atsuko Hara; Makoto Saegusa
Journal:  PLoS One       Date:  2017-08-24       Impact factor: 3.240

5.  IDH mutation status is associated with distinct vascular gene expression signatures in lower-grade gliomas.

Authors:  Lei Zhang; Liqun He; Roberta Lugano; Kenney Roodakker; Michael Bergqvist; Anja Smits; Anna Dimberg
Journal:  Neuro Oncol       Date:  2018-10-09       Impact factor: 13.029

6.  Uncovering a Key Role of ETS1 on Vascular Abnormality in Glioblastoma.

Authors:  Jiefu Tang; Yaling Li; Boxuan Liu; Wei Liang; Sanbao Hu; Meilian Shi; Jie Zeng; Mingzhen Li; Minjiang Huang
Journal:  Pathol Oncol Res       Date:  2021-11-19       Impact factor: 3.201
  6 in total

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