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Literature DB >> 28090330

Mechanochemical functionalization of disulfide linked hydrogels.

Junmin Lee¹, Meredith N Silberstein², Amr A Abdeen¹, Sang Yup Kim³, Kristopher A Kilian¹.

Abstract

Poly(ethylene glycol) hydrogels with disulfide linkages are functionalized through applied force. Compression or tension induces bond rupture at the relatively weak disulfide linkages, which will subsequently react through Michael-type addition with an acceptor molecule within the gel. We demonstrate the utility of this approach by patterning cell adhesion proteins through compression of a lithographically structured stamp, where cells predominately adhere to the compressed regions.

Entities: CellLine Chemical Disease Gene Species

Year: 2016 PMID： 28090330 PMCID： PMC5228622 DOI： 10.1039/C6MH00091F

Source DB: PubMed Journal: Mater Horiz ISSN： 2051-6347 Impact factor: 13.266

20 in total

Review 1. Hydrogels for tissue engineering: scaffold design variables and applications.

Authors: Jeanie L Drury; David J Mooney
Journal: Biomaterials Date: 2003-11 Impact factor: 12.479

2. Force-dependent chemical kinetics of disulfide bond reduction observed with single-molecule techniques.

Authors: Arun P Wiita; Sri Rama Koti Ainavarapu; Hector H Huang; Julio M Fernandez
Journal: Proc Natl Acad Sci U S A Date: 2006-04-27 Impact factor: 11.205

3. Convergent synthesis of 3-arm star polymers from RAFT-prepared poly(N,N-diethylacrylamide) via a thiol-ene click reaction.

Authors: Justin W Chan; Bing Yu; Charles E Hoyle; Andrew B Lowe
Journal: Chem Commun (Camb) Date: 2008-09-19 Impact factor: 6.222

4. Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration.

Authors: Soo-Hong Lee; James J Moon; Jennifer L West
Journal: Biomaterials Date: 2008-04-22 Impact factor: 12.479

Mechanochemical functionalization of disulfide linked hydrogels.

Review 1. Hydrogels for tissue engineering: scaffold design variables and applications.

2. Force-dependent chemical kinetics of disulfide bond reduction observed with single-molecule techniques.

3. Convergent synthesis of 3-arm star polymers from RAFT-prepared poly(N,N-diethylacrylamide) via a thiol-ene click reaction.

4. Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration.

Review 5. Applications of orthogonal "click" chemistries in the synthesis of functional soft materials.

Review 6. Hyaluronic acid hydrogels for biomedical applications.

7. Copper-free click chemistry for the in situ crosslinking of photodegradable star polymers.

8. Photodegradable, Photoadaptable Hydrogels via Radical-Mediated Disulfide Fragmentation Reaction.

9. The fibrinogen molecule: its size, shape, and mode of polymerization.

Review 10. Thiol-ene and photo-cleavage chemistry for controlled presentation of biomolecules in hydrogels.

Review 1. Elastomer-Hydrogel Systems: From Bio-Inspired Interfaces to Medical Applications.