Teresa M Ward1,2, Dean W Beebe3,4, Maida Lynn Chen3,4, Carol A Landis3,4, Sarah Ringold3,4, Ken Pike3,4, Carol A Wallace3,4. 1. From the School of Nursing, University of Washington; Seattle Children's Hospital, Department of Pediatrics, Division of Pulmonary and Sleep Medicine, University of Washington School of Medicine; Seattle Children's Hospital, Department of Pediatrics, Division of Rheumatology, University of Washington School of Medicine, Seattle, Washington; Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. teward@uw.edu. 2. T.M. Ward, PhD, Associate Professor, School of Nursing, University of Washington; D.W. Beebe, PhD, ABPP, Professor, Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine; M.L. Chen, MD, Associate Professor, Seattle Children's Hospital, Department of Pediatrics, Division of Pulmonary and Sleep Medicine, University of Washington School of Medicine; C.A. Landis, PhD, Professor, School of Nursing, University of Washington; S. Ringold, MS, MD, Associate Professor, Seattle Children's Hospital, Department of Pediatrics, Division of Rheumatology, University of Washington School of Medicine; K. Pike, PhD, Statistician, School of Nursing, University of Washington; C.A. Wallace, MD, Professor, Seattle Children's Hospital, Department of Pediatrics, Division of Rheumatology, University of Washington School of Medicine. teward@uw.edu. 3. From the School of Nursing, University of Washington; Seattle Children's Hospital, Department of Pediatrics, Division of Pulmonary and Sleep Medicine, University of Washington School of Medicine; Seattle Children's Hospital, Department of Pediatrics, Division of Rheumatology, University of Washington School of Medicine, Seattle, Washington; Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. 4. T.M. Ward, PhD, Associate Professor, School of Nursing, University of Washington; D.W. Beebe, PhD, ABPP, Professor, Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine; M.L. Chen, MD, Associate Professor, Seattle Children's Hospital, Department of Pediatrics, Division of Pulmonary and Sleep Medicine, University of Washington School of Medicine; C.A. Landis, PhD, Professor, School of Nursing, University of Washington; S. Ringold, MS, MD, Associate Professor, Seattle Children's Hospital, Department of Pediatrics, Division of Rheumatology, University of Washington School of Medicine; K. Pike, PhD, Statistician, School of Nursing, University of Washington; C.A. Wallace, MD, Professor, Seattle Children's Hospital, Department of Pediatrics, Division of Rheumatology, University of Washington School of Medicine.
Abstract
OBJECTIVE: To examine the extent of polysomnographic (PSG) sleep disturbances [obstructive apnea hypopnea index (OAHI), number of wake bouts, arousals, periodic limb movements] and the effect of OAHI on neurobehavioral performance in juvenile idiopathic arthritis (JIA) with obstructive sleep apnea (OSA), JIA without OSA, and controls without OSA, adjusting for intelligence quotient (IQ), pain, medications, daytime sleepiness, and wake bouts. METHODS: Children 6-11 years, 68 with JIA and 67 controls, underwent 1 night of PSG and completed self-reported daytime sleepiness surveys, multiple sleep latency tests for physiological sleepiness, and neurobehavioral performance tests the next day. RESULTS: Compared with JIA and controls without OSA, mean OAHI and arousals were significantly higher in JIA with OSA (p < 0.001, respectively). In comparison with JIA and controls without OSA, mean simple reaction time and sustained attention were significantly slower in JIA with OSA, adjusting for IQ, pain, any medication, daytime sleepiness, and wake bouts. CONCLUSION: Elevated OAHI is suggestive of obstructive sleep apnea and a comorbidity in JIA that may predispose children with JIA to daytime sleepiness and impaired neurobehavioral performance.
OBJECTIVE: To examine the extent of polysomnographic (PSG) sleep disturbances [obstructive apnea hypopnea index (OAHI), number of wake bouts, arousals, periodic limb movements] and the effect of OAHI on neurobehavioral performance in juvenile idiopathic arthritis (JIA) with obstructive sleep apnea (OSA), JIA without OSA, and controls without OSA, adjusting for intelligence quotient (IQ), pain, medications, daytime sleepiness, and wake bouts. METHODS:Children 6-11 years, 68 with JIA and 67 controls, underwent 1 night of PSG and completed self-reported daytime sleepiness surveys, multiple sleep latency tests for physiological sleepiness, and neurobehavioral performance tests the next day. RESULTS: Compared with JIA and controls without OSA, mean OAHI and arousals were significantly higher in JIA with OSA (p < 0.001, respectively). In comparison with JIA and controls without OSA, mean simple reaction time and sustained attention were significantly slower in JIA with OSA, adjusting for IQ, pain, any medication, daytime sleepiness, and wake bouts. CONCLUSION: Elevated OAHI is suggestive of obstructive sleep apnea and a comorbidity in JIA that may predispose children with JIA to daytime sleepiness and impaired neurobehavioral performance.
Authors: Teresa M Ward; Kristen Archbold; Martha Lentz; Sarah Ringold; Carol A Wallace; Carol A Landis Journal: Sleep Date: 2010-02 Impact factor: 5.849
Authors: Ronald D Chervin; Robert A Weatherly; Deborah L Ruzicka; Joseph W Burns; Bruno J Giordani; James E Dillon; Carole L Marcus; Susan L Garetz; Timothy F Hoban; Kenneth E Guire Journal: Sleep Date: 2006-04 Impact factor: 5.849
Authors: Robert S Bourke; Vicki Anderson; Joel S C Yang; Angela R Jackman; Asawari Killedar; Gillian M Nixon; Margot J Davey; Adrian M Walker; John Trinder; Rosemary S C Horne Journal: Sleep Med Date: 2011-02-15 Impact factor: 3.492
Authors: H Gerry Taylor; Susan R Bowen; Dean W Beebe; Elise Hodges; Raouf Amin; Raanan Arens; Ronald D Chervin; Susan L Garetz; Eliot S Katz; Reneé H Moore; Knashawn H Morales; Hiren Muzumdar; Shalini Paruthi; Carol L Rosen; Anjali Sadhwani; Nina Hattiangadi Thomas; Janice Ware; Carole L Marcus; Susan S Ellenberg; Susan Redline; Bruno Giordani Journal: Pediatrics Date: 2016-08 Impact factor: 7.124
Authors: Cassia M Passarelli; Suely Roizenblatt; Claudio A Len; Gustavo A Moreira; Maria Cecilia Lopes; Christian Guilleminault; Sergio Tufik; Maria Odete E Hilario Journal: J Rheumatol Date: 2006-03-01 Impact factor: 4.666
Authors: Brooks B Gump; Kevin S Heffernan; Kestutis Bendinskas; Bryce Hruska; James A MacKenzie; Aesoon Park; Lynn S Brann; Nader H Atallah-Yunes Journal: Psychosom Med Date: 2021-04-01 Impact factor: 3.864