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Literature DB >> 28089822

MicroRNAs in pituitary tumors.

Anne Wierinckx¹, Magali Roche², Catherine Legras-Lachuer³, Jacqueline Trouillas⁴, Gérald Raverot⁵, Joël Lachuer⁶.

Abstract

Since the presence of microRNAs was first observed in normal pituitary, the majority of scientific publications addressing their role and the function of microRNAs in the pituitary have been based on pituitary tumor studies. In this review, we briefly describe the involvement of microRNAs in the synthesis of pituitary hormones and we present a comprehensive inventory of microRNA suppressors and inducers of pituitary tumors. Finally, we summarize the functional role of microRNAs in tumorigenesis, progression and aggressiveness of pituitary tumors, mechanisms contributing to the regulation (transcription factors, genomic modifications or epigenetic) or modulation (pharmacological treatment) of microRNAs in these tumors, and the interest of thoroughly studying the expression of miRNAs in body fluids.

Entities: Disease

Keywords: Pituitary tumors; microRNAs

Mesh：

Substances：

Year: 2017 PMID： 28089822 DOI： 10.1016/j.mce.2017.01.021

Source DB: PubMed Journal: Mol Cell Endocrinol ISSN： 0303-7207 Impact factor: 4.102

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Cited

18 in total

Review 1. Prognostic factors of regrowth in nonfunctioning pituitary tumors.

Authors: Gerald Raverot; Alexandre Vasiljevic; Emmanuel Jouanneau
Journal: Pituitary Date: 2018-04 Impact factor: 4.107

Review 2. Recent Understanding and Future Directions of Recurrent Corticotroph Tumors.

Authors: José Miguel Hinojosa-Amaya; César Ernesto Lam-Chung; Daniel Cuevas-Ramos
Journal: Front Endocrinol (Lausanne) Date: 2021-04-26 Impact factor: 5.555

3. Identification and characterization of microRNAs in the pituitary of pubescent goats.

Authors: Jing Ye; Zhiqiu Yao; Wenyu Si; Xiaoxiao Gao; Chen Yang; Ya Liu; Jianping Ding; Weiping Huang; Fugui Fang; Jie Zhou
Journal: Reprod Biol Endocrinol Date: 2018-05-25 Impact factor: 5.211

4. Increased E2F1 mRNA and miR-17-5p Expression Is Correlated to Invasiveness and Proliferation of Pituitary Neuroendocrine Tumours.

Authors: Araceli García-Martínez; Beatriz López-Muñoz; Carmen Fajardo; Rosa Cámara; Cristina Lamas; Sandra Silva-Ortega; Ignacio Aranda; Antonio Picó
Journal: Diagnostics (Basel) Date: 2020-04-16

5. Circulating Plasma microRNA to Differentiate Cushing's Disease From Ectopic ACTH Syndrome.

Authors: Zhanna Belaya; Patimat Khandaeva; Larisa Nonn; Alexey Nikitin; Alexander Solodovnikov; Ivan Sitkin; Andrey Grigoriev; Mikhail Pikunov; Anastasia Lapshina; Liudmila Rozhinskaya; Galina Melnichenko; Ivan Dedov
Journal: Front Endocrinol (Lausanne) Date: 2020-06-05 Impact factor: 5.555

6. MicroRNA-186 targets SKP2 to induce p27^Kip1-mediated pituitary tumor cell cycle deregulation and modulate cell proliferation.

Authors: Zongze He; Longyi Chen; Qi Wang; Cheng Yin; Junting Hu; Xiao Hu; Fan Fei; Jian Tang
Journal: Korean J Physiol Pharmacol Date: 2019-04-24 Impact factor: 2.016

7. Increased expression of the microRNA 106b~25 cluster and its host gene MCM7 in corticotroph pituitary adenomas is associated with tumor invasion and Crooke's cell morphology.

Authors: Filip Garbicz; Dawid Mehlich; Beata Rak; Emir Sajjad; Maria Maksymowicz; Wiktor Paskal; Grzegorz Zieliński; Paweł K Włodarski
Journal: Pituitary Date: 2017-08 Impact factor: 4.107

MicroRNAs in pituitary tumors.

Review 1. Prognostic factors of regrowth in nonfunctioning pituitary tumors.

Review 2. Recent Understanding and Future Directions of Recurrent Corticotroph Tumors.

3. Identification and characterization of microRNAs in the pituitary of pubescent goats.

4. Increased E2F1 mRNA and miR-17-5p Expression Is Correlated to Invasiveness and Proliferation of Pituitary Neuroendocrine Tumours.

5. Circulating Plasma microRNA to Differentiate Cushing's Disease From Ectopic ACTH Syndrome.

6. MicroRNA-186 targets SKP2 to induce p27^Kip1-mediated pituitary tumor cell cycle deregulation and modulate cell proliferation.

7. Increased expression of the microRNA 106b~25 cluster and its host gene MCM7 in corticotroph pituitary adenomas is associated with tumor invasion and Crooke's cell morphology.

Review 8. Pituitary-Directed Therapies for Cushing's Disease.

Review 9. Recent advances in understanding corticotroph pituitary tumor initiation and progression.

10. MiR-15a/miR-16-1 expression inversely correlates with cyclin D1 levels in Men1 pituitary NETs.

MicroRNAs in pituitary tumors.

Review 1. Prognostic factors of regrowth in nonfunctioning pituitary tumors.

Review 2. Recent Understanding and Future Directions of Recurrent Corticotroph Tumors.

3. Identification and characterization of microRNAs in the pituitary of pubescent goats.

4. Increased E2F1 mRNA and miR-17-5p Expression Is Correlated to Invasiveness and Proliferation of Pituitary Neuroendocrine Tumours.

5. Circulating Plasma microRNA to Differentiate Cushing's Disease From Ectopic ACTH Syndrome.

6. MicroRNA-186 targets SKP2 to induce p27Kip1-mediated pituitary tumor cell cycle deregulation and modulate cell proliferation.

7. Increased expression of the microRNA 106b~25 cluster and its host gene MCM7 in corticotroph pituitary adenomas is associated with tumor invasion and Crooke's cell morphology.

Review 8. Pituitary-Directed Therapies for Cushing's Disease.

Review 9. Recent advances in understanding corticotroph pituitary tumor initiation and progression.

10. MiR-15a/miR-16-1 expression inversely correlates with cyclin D1 levels in Men1 pituitary NETs.

6. MicroRNA-186 targets SKP2 to induce p27^Kip1-mediated pituitary tumor cell cycle deregulation and modulate cell proliferation.