Pekka Pinola1, Katri Puukka2, Terhi T Piltonen1, Johanna Puurunen1, Eszter Vanky3, Inger Sundström-Poromaa4, Elisabet Stener-Victorin5, Angelica Lindén Hirschberg6, Pernille Ravn7, Marianne Skovsager Andersen8, Dorte Glintborg8, Jan Roar Mellembakken9, Aimo Ruokonen2, Juha S Tapanainen10, Laure C Morin-Papunen11. 1. Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland; University of Oulu and Medical Research Center Oulu, Oulu, Finland. 2. University of Oulu and Medical Research Center Oulu, Oulu, Finland; Nordlab Oulu, Oulu University Hospital and Department of Clinical Chemistry, University of Oulu, Oulu, Finland. 3. Institute of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway; Department of Obstetrics and Gynecology, St. Olav's University Hospital Trondheim, Trondheim, Norway. 4. Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. 5. Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. 6. Department of Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, Sweden. 7. Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark. 8. Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark. 9. Section of Reproductive Medicine, Department of Gynecology, Women's Division, Oslo University Hospital, Oslo, Norway. 10. University of Oulu and Medical Research Center Oulu, Oulu, Finland; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. 11. Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland; University of Oulu and Medical Research Center Oulu, Oulu, Finland. Electronic address: lmp@cc.oulu.fi.
Abstract
OBJECTIVE: To compare the metabolic profiles of normo- and hyperandrogenic women with polycystic ovary syndrome (PCOS) with those of control women at different ages during reproductive life. DESIGN: Case-control study. SETTING: Not applicable. PATIENT(S): In all, 1,550 women with normoandrogenic (n = 686) or hyperandrogenic (n = 842) PCOS and 447 control women were divided into three age groups: <30, 30-39, and >39 years). INTERVENTIONS(S): None. MAIN OUTCOME MEASURE(S): Body mass index (BMI), waist circumference, blood pressure, glucose, insulin, cholesterol, lipoproteins, triglycerides and high-sensitivity C-reactive protein. RESULT(S): Both normo- and hyperandrogenic women with PCOS were more obese, especially abdominally. They had increased serum levels of insulin (fasting and in oral glucose tolerance tests), triglycerides, low-density lipoprotein, and total cholesterol, higher blood pressure, and lower high-density lipoprotein levels independently from BMI compared with the control population as early as from young adulthood until menopause. The prevalence of metabolic syndrome was two- to fivefold higher in women with PCOS compared with control women, depending on age and phenotype, and the highest prevalence was observed in hyperandrogenic women with PCOS at late reproductive age. CONCLUSION(S): When evaluating metabolic risks in women with PCOS, androgenic status, especially abdominal obesity and age, should be taken into account, which would allow tailored management of the syndrome from early adulthood on.
OBJECTIVE: To compare the metabolic profiles of normo- and hyperandrogenicwomen with polycystic ovary syndrome (PCOS) with those of control women at different ages during reproductive life. DESIGN: Case-control study. SETTING: Not applicable. PATIENT(S): In all, 1,550 women with normoandrogenic (n = 686) or hyperandrogenic (n = 842) PCOS and 447 control women were divided into three age groups: <30, 30-39, and >39 years). INTERVENTIONS(S): None. MAIN OUTCOME MEASURE(S): Body mass index (BMI), waist circumference, blood pressure, glucose, insulin, cholesterol, lipoproteins, triglycerides and high-sensitivity C-reactive protein. RESULT(S): Both normo- and hyperandrogenicwomen with PCOS were more obese, especially abdominally. They had increased serum levels of insulin (fasting and in oral glucose tolerance tests), triglycerides, low-density lipoprotein, and total cholesterol, higher blood pressure, and lower high-density lipoprotein levels independently from BMI compared with the control population as early as from young adulthood until menopause. The prevalence of metabolic syndrome was two- to fivefold higher in women with PCOS compared with control women, depending on age and phenotype, and the highest prevalence was observed in hyperandrogenicwomen with PCOS at late reproductive age. CONCLUSION(S): When evaluating metabolic risks in women with PCOS, androgenic status, especially abdominal obesity and age, should be taken into account, which would allow tailored management of the syndrome from early adulthood on.
Authors: Qing Peng; Carrie A Karvonen-Gutierrez; John F Randolph; Bin Nan; Daniel McConnell; Siobán D Harlow Journal: J Clin Endocrinol Metab Date: 2019-05-01 Impact factor: 5.958
Authors: Edgar D Torres Fernandez; Alexandra M Huffman; Maryam Syed; Damian G Romero; Licy L Yanes Cardozo Journal: Endocrinology Date: 2019-12-01 Impact factor: 4.736
Authors: Kim van der Ham; Charissa van Zwol-Janssens; Birgitta K Velthuis; Maria P H Koster; Yvonne V Louwers; Dustin Goei; Maurits S H Blomjous; Arie Franx; Bart C J M Fauser; Eric Boersma; Joop S E Laven; Ricardo P J Budde Journal: Insights Imaging Date: 2022-06-04