Literature DB >> 28089302

Germinal Center Lymphocyte Ratios and Successful HIV Vaccines.

Paula Gonzalez-Figueroa1, Jonathan A Roco1, Carola G Vinuesa2.   

Abstract

Current HIV vaccines are poor inducers of neutralizing antibodies (nAbs). A recent study in Cell Reports used serial fine-needle aspirates from rhesus macaque lymph nodes following HIV-1 surface envelope glycoprotein (Env) trimer immunization, generating a substantial production of HIV-1 nAbs. A remarkable correlation was found between antibody titers and a high frequency and ratio of germinal center B and T follicular helper (TFH) lymphocytes.
Copyright © 2016. Published by Elsevier Ltd.

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Year:  2017        PMID： 28089302     DOI： 10.1016/j.molmed.2016.12.009

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  5 in total

1.  BCL6 BTB-specific inhibition via FX1 treatment reduces Tfh cells and reverses lymphoid follicle hyperplasia in Indian rhesus macaque (Macaca mulatta).

Authors:  Yanhui Cai; Meagan A Watkins; Fengtian Xue; Yong Ai; Huiming Cheng; Cecily C Midkiff; Xiaolei Wang; Xavier Alvarez; Adi Narayana Reddy Poli; Joseph M Salvino; Ronald S Veazey; Luis J Montaner
Journal:  J Med Primatol       Date:  2019-10-01       Impact factor: 0.667

2.  BCL6 Inhibitor-Mediated Downregulation of Phosphorylated SAMHD1 and T Cell Activation Are Associated with Decreased HIV Infection and Reactivation.

Authors:  Yanhui Cai; Mohamed Abdel-Mohsen; Costin Tomescu; Fengtian Xue; Guoxin Wu; Bonnie J Howell; Yong Ai; Jie Sun; Livio Azzoni; Carole Le Coz; Neil Romberg; Luis J Montaner
Journal:  J Virol       Date:  2019-01-04       Impact factor: 5.103

3.  Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches.

Authors:  Matthias Pauthner; Colin Havenar-Daughton; Devin Sok; Joseph P Nkolola; Raiza Bastidas; Archana V Boopathy; Diane G Carnathan; Abishek Chandrashekar; Kimberly M Cirelli; Christopher A Cottrell; Alexey M Eroshkin; Javier Guenaga; Kirti Kaushik; Daniel W Kulp; Jinyan Liu; Laura E McCoy; Aaron L Oom; Gabriel Ozorowski; Kai W Post; Shailendra K Sharma; Jon M Steichen; Steven W de Taeye; Talar Tokatlian; Alba Torrents de la Peña; Salvatore T Butera; Celia C LaBranche; David C Montefiori; Guido Silvestri; Ian A Wilson; Darrell J Irvine; Rogier W Sanders; William R Schief; Andrew B Ward; Richard T Wyatt; Dan H Barouch; Shane Crotty; Dennis R Burton
Journal:  Immunity       Date:  2017-06-20       Impact factor: 31.745

Review 4.  T Follicular Helper Cells As a New Target for Immunosuppressive Therapies.

Authors:  Lin Yan; Kitty de Leur; Rudi W Hendriks; Luc J W van der Laan; Yunying Shi; Lanlan Wang; Carla C Baan
Journal:  Front Immunol       Date:  2017-11-07       Impact factor: 7.561

Review 5.  Follicular Dendritic Cells of Lymph Nodes as Human Immunodeficiency Virus/Simian Immunodeficiency Virus Reservoirs and Insights on Cervical Lymph Node.

Authors:  Rajnish S Dave; Pooja Jain; Siddappa N Byrareddy
Journal:  Front Immunol       Date:  2018-04-19       Impact factor: 7.561
  5 in total

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