José Eduardo Batista1, Vera Aparecida Saddi2, Keila Patrícia Almeida de Carvalho3, Andréa Alves Ribeiro3, Kelly Deyse Segati3, Megmar Aparecida Dos S Carneiro3, Silvio G Monteiro4, Maria do Desterro S B Nascimento5, Silvia Helena Rabelo-Santos6. 1. Department of Pathology, Biological and Health Sciences Center, Federal University of Maranhão, Avenida dos Portugueses SN, CEP 65025-560, São Luís, MA, Brazil. Electronic address: jbatistaufma@gmail.com. 2. Pontifical Catholic University of Goiás, Goiânia, GO, Brazil. 3. Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, Brazil. 4. Health Sciences Center, CEUMA University, São Luís, MA, Brazil; Department of Biological Sciences, Federal University of Maranhão, São Luís, MA, Brazil. 5. Department of Pathology, Biological and Health Sciences Center, Federal University of Maranhão, Avenida dos Portugueses SN, CEP 65025-560, São Luís, MA, Brazil. 6. Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, Brazil; School of Pharmacy, Federal University of Goiás, Goiânia, GO, Brazil.
Abstract
OBJECTIVES: To determine the frequency of human papillomavirus (HPV) types and behavioral characteristics related to cytological abnormalities in women descendants of slaves, who live in isolated communities known as quilombos in the state of Maranhão, Brazil. METHODS: Cervicovaginal specimens of 353 women were analyzed by conventional cytology and genotyping. HPV detection and genotyping was performed using a linear array HPV genotyping test kit. Behavioral factors and their association with cytological abnormalities were analyzed, as well as the association between cytological abnormalities and HPV infection. RESULTS: The frequency of HPV infection was 13%, and infection with high-risk HPV types was more frequent than with low-risk types (10.2% vs. 2.8%). The most prevalent genotypes were HPV 68 (3.1%) and HPV 58 (2.6%). HPV-positive women were 6.5 times more likely than HPV-negative women to be diagnosed with cytological abnormalities. There was a significant association between HPV infection and the presence of cytological abnormalities in women 31-40 years of age and in women 51-60 years of age. CONCLUSIONS: A distinct profile of high-risk HPV genotypes was detected, with predominance of types 68 and 58. It is possible that the results of the present study are due to specific characteristics of the population, which is geographically isolated and maintains conservative sexual habits.
OBJECTIVES: To determine the frequency of human papillomavirus (HPV) types and behavioral characteristics related to cytological abnormalities in women descendants of slaves, who live in isolated communities known as quilombos in the state of Maranhão, Brazil. METHODS: Cervicovaginal specimens of 353 women were analyzed by conventional cytology and genotyping. HPV detection and genotyping was performed using a linear array HPV genotyping test kit. Behavioral factors and their association with cytological abnormalities were analyzed, as well as the association between cytological abnormalities and HPV infection. RESULTS: The frequency of HPV infection was 13%, and infection with high-risk HPV types was more frequent than with low-risk types (10.2% vs. 2.8%). The most prevalent genotypes were HPV 68 (3.1%) and HPV 58 (2.6%). HPV-positive women were 6.5 times more likely than HPV-negative women to be diagnosed with cytological abnormalities. There was a significant association between HPV infection and the presence of cytological abnormalities in women 31-40 years of age and in women 51-60 years of age. CONCLUSIONS: A distinct profile of high-risk HPV genotypes was detected, with predominance of types 68 and 58. It is possible that the results of the present study are due to specific characteristics of the population, which is geographically isolated and maintains conservative sexual habits.
Authors: I G S S Serra; E D Araujo; G S Barros; F L S G Santos; R Q Gurgel; M V A Batista Journal: Epidemiol Infect Date: 2018-05-21 Impact factor: 4.434