Stamatis Georgopoulos1, Konstantinos P Letsas1, Tong Liu2, Maria Kalafateli1, Panagiotis Korantzopoulos3, Gerd Bürkle4, Konstantinos Vlachos1, Georgios Giannopoulos5, Michael Efremidis1, Spyridon Deftereos5, Antonios Sideris1, Masahiko Takagi6, Gan-Xin Yan7,8, Joachim R Ehrlich4. 1. Laboratory of Cardiac Electrophysiology, "Evangelismos" General Hospital of Athens, Greece. 2. Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, People's Republic of China. 3. Department of Cardiology, University Hospital of Ioannina, Greece. 4. Electrophysiology Section, St. Josefs-Hospital, Wiesbaden, Germany. 5. Second Department of Cardiology, University of Athens Medical School, Attikon University Hospital, Greece. 6. Department of Cardiovascular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan. 7. Lankenau Institute for Medical Research, Wynnewood, PA, USA. 8. Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Abstract
Aims: The early repolarization (ER) pattern has been linked to an increased risk for arrhythmic death in various clinical settings. There are limited and conflicting data regarding the prognostic significance of ER pattern in Brugada syndrome (BS). The aim of this meta-analysis was to provide a detailed analysis of the currently available studies regarding the arrhythmic risk in patients with BS and ER pattern. Methods and results: Current databases were searched until May 2015. A random-effect meta-analysis of the effect of ER pattern on the incidence of arrhythmic events in patients with BS was performed. Five studies were included comprising a total of 1375 patients with BS. An ER pattern was reported in 177 patients (12.8%). During follow-up (44.9-93 months), 143 patients (10.4%) suffered an arrhythmic event. Overall, BS patients with ER pattern displayed an increased risk of arrhythmic events compared to patients without ER (OR 3.29, 95% CI: 2.06 to 5.26, P < 0.00001; Heterogeneity: P = 0.11, I2 = 48%). Three studies provided data regarding ER pattern location. Inferior, lateral, or inferolateral ER pattern location was observed in 20.3%, 32.2%, and 48%, respectively. An inferolateral ER location conferred the higher arrhythmic risk (OR 4.87, 95% CI: 2.64 to 9.01, P< 0.00001; Heterogeneity: P = 0.85, I2 = 0%). Conclusion: This meta-analysis suggests that the ER pattern is associated with a high risk of arrhythmic events in patients with BS. In particular, BS patients with inferolateral ER (global ER pattern) displayed the highest arrhythmic risk. Published on behalf of the European Society of Cardiology. All rights reserved.
Aims: The early repolarization (ER) pattern has been linked to an increased risk for arrhythmic death in various clinical settings. There are limited and conflicting data regarding the prognostic significance of ER pattern in Brugada syndrome (BS). The aim of this meta-analysis was to provide a detailed analysis of the currently available studies regarding the arrhythmic risk in patients with BS and ER pattern. Methods and results: Current databases were searched until May 2015. A random-effect meta-analysis of the effect of ER pattern on the incidence of arrhythmic events in patients with BS was performed. Five studies were included comprising a total of 1375 patients with BS. An ER pattern was reported in 177 patients (12.8%). During follow-up (44.9-93 months), 143 patients (10.4%) suffered an arrhythmic event. Overall, BSpatients with ER pattern displayed an increased risk of arrhythmic events compared to patients without ER (OR 3.29, 95% CI: 2.06 to 5.26, P < 0.00001; Heterogeneity: P = 0.11, I2 = 48%). Three studies provided data regarding ER pattern location. Inferior, lateral, or inferolateral ER pattern location was observed in 20.3%, 32.2%, and 48%, respectively. An inferolateral ER location conferred the higher arrhythmic risk (OR 4.87, 95% CI: 2.64 to 9.01, P< 0.00001; Heterogeneity: P = 0.85, I2 = 0%). Conclusion: This meta-analysis suggests that the ER pattern is associated with a high risk of arrhythmic events in patients with BS. In particular, BSpatients with inferolateral ER (global ER pattern) displayed the highest arrhythmic risk. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Mohammad Iqbal; Iwan Cahyo Santosa Putra; Raymond Pranata; Michael Nathaniel Budiarso; Miftah Pramudyo; Hanna Goenawan; Mohammad Rizki Akbar; Arief Sjamsulaksan Kartasasmita Journal: Front Cardiovasc Med Date: 2022-06-17
Authors: Dimitrios Asvestas; Gary Tse; Adrian Baranchuk; George Bazoukis; Tong Liu; Athanasios Saplaouras; Panagiotis Korantzopoulos; Christina Goga; Michael Efremidis; Antonios Sideris; Konstantinos P Letsas Journal: Int J Cardiol Heart Vasc Date: 2018-03-08