J I Rojas1, L Patrucco2, J MIguez2, V Sinay3, F Pagani Cassara3, F Cáceres4, N Fernandez Liguori4, M L Saladino4, N Deri5, G Jaacks5, M Parada Marcilla6, M I Arrigoni7, J Correale8, M Fiol8, M C Ysrraelit8, A Carrá9, M C Curbelo9, A Martinez9, J Steinberg9, S Bestoso10, J P Hryb11, J L Di Pace11, M B Perassolo11, E Carnero Contentti12, A Caride12, P A Lopez12, C Martinez6, E Reich13, D Giunta2, E Cristiano2. 1. Centro de Esclerosis Múltiple de Buenos Aires, Hospital Italiano de Buenos Aires, Argentina. Electronic address: juan.rojas@hospitalitaliano.org.ar. 2. Centro de Esclerosis Múltiple de Buenos Aires, Hospital Italiano de Buenos Aires, Argentina. 3. Instituto de Neurociencias Fundación Favaloro (INCyT), Argentina. 4. Neurosciences Institute of Buenos Aires (INEBA), Buenos Aires, Argentina. 5. Centro de Investigación DIABAID, Argentina. 6. Private Office, Argentina. 7. Hospital Italiano de Córdoba, Argentina. 8. Department of Neurology, Institute for Neurological Research Dr. Raúl Carrea, FLENI, Argentina. 9. Hospital Británico Buenos Aires, Argentina. 10. Hospital Escuela "José F. De San Martín", Corrientes, Argentina. 11. Hospital General de Agudos Carlos G Durand, Buenos Aires, Argentina. 12. Hospital Alemán, Buenos Aires, Argentina. 13. Hospital Julio Mendez, Buenos Aires, Argentina.
Abstract
Several studies in multiple sclerosis (MS) suggest a trend of increasing disease frequency in women during the last decades. A direct comparison of gender ratio trends among MS populations from Argentina remains to be carried out. The objective of the study was to compare gender ratio trends, over a 50-year span in MS populations from Argentina. METHODS: multicenter study that included patients from 14 MS Centers of Argentina. Patients with definite MS with birth years ranging from 1940 to 1989 were included. Gender ratios were calculated by five decades based on year of birth and were adjusted for the F/M born-alive ratio derived from the Argentinean national registry of births. The F/M ratios were calculated using a multivariate logistic regression per five decades by the year of birth approach. Analyses were performed using Stata 10.1. RESULTS: 1069 patients were included. Gender ratios showed a significant increase from the first to the last decade in the whole MS sample (from 1.8 to 2.7; p value for trend=0.023). The Gender ratio did not show differences considering MS subtype. CONCLUSION: our study showed a modest increase of the F/M ratio (from 1.8 to 2.7) over time among patients affected by MS in Argentina.
Several studies in multiple sclerosis (MS) suggest a trend of increasing disease frequency in women during the last decades. A direct comparison of gender ratio trends among MS populations from Argentina remains to be carried out. The objective of the study was to compare gender ratio trends, over a 50-year span in MS populations from Argentina. METHODS: multicenter study that included patients from 14 MS Centers of Argentina. Patients with definite MS with birth years ranging from 1940 to 1989 were included. Gender ratios were calculated by five decades based on year of birth and were adjusted for the F/M born-alive ratio derived from the Argentinean national registry of births. The F/M ratios were calculated using a multivariate logistic regression per five decades by the year of birth approach. Analyses were performed using Stata 10.1. RESULTS: 1069 patients were included. Gender ratios showed a significant increase from the first to the last decade in the whole MS sample (from 1.8 to 2.7; p value for trend=0.023). The Gender ratio did not show differences considering MS subtype. CONCLUSION: our study showed a modest increase of the F/M ratio (from 1.8 to 2.7) over time among patients affected by MS in Argentina.