Literature DB >> 28086071

155R is a novel structural protein of bovine adenovirus type 3, but it is not essential for virus replication.

Ahmed O Hassan1,2,3, Sai V Vemula1,3,4, Anurag Sharma1,3,5, Dinesh S Bangari1,3,6, Krishna K Mishra1,3,7, Suresh K Mittal1,2,3.   

Abstract

Bovine adenovirus (AdV) type 3 (BAdV-3) E1 region shares functional homology with E1 of human AdV type C5. Sequence analysis of the BAdV-3 E1 region revealed the presence of a novel 155R ORF that is not observed in other AdVs, on the lower strand antiparallel to a portion of the E1B region. The 155R gene products in BAdV-3-infected cells were identified by Northern blot, reverse transcriptase PCR followed by sequencing and Western blot analysis using the155R-specific antibody. 155R seems to be a late protein and is present in purified BAdV-3 particles. Replication kinetics of BAdV mutants with either one (BAdV/155R/mt1) or two (BAdV/155R/mt2) stop codons in the 155R ORF were comparable to those of BAdV-3, indicating that 155R is not essential for virus replication in cell culture. These results suggest that 155R-deleted BAdV-3 vectors could be generated in a cell line that fully complements BAdV-3 E1 functions.

Entities:  

Mesh：

Substances：

Year:  2017        PMID： 28086071      PMCID： PMC5721929          DOI： 10.1099/jgv.0.000707

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  34 in total

1.  The coiled-coil domain of the adenovirus type 5 protein IX is dispensable for capsid incorporation and thermostability.

Authors:  Jort Vellinga; Diana J M van den Wollenberg; Stephanie van der Heijdt; Martijn J W E Rabelink; Rob C Hoeben
Journal:  J Virol       Date:  2005-03       Impact factor: 5.103

2.  Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism.

Authors:  V N Krasnykh; G V Mikheeva; J T Douglas; D T Curiel
Journal:  J Virol       Date:  1996-10       Impact factor: 5.103

3.  Nucleotide sequence, genome organization, and transcription map of bovine adenovirus type 3.

Authors:  P S Reddy; N Idamakanti; A N Zakhartchouk; M K Baxi; J B Lee; C Pyne; L A Babiuk; S K Tikoo
Journal:  J Virol       Date:  1998-02       Impact factor: 5.103

4.  Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes.

Authors:  M Kozak
Journal:  Nucleic Acids Res       Date:  1981-10-24       Impact factor: 16.971

Review 5.  Production of adenovirus vectors and their use as a delivery system for influenza vaccines.

Authors:  Sai V Vemula; Suresh K Mittal
Journal:  Expert Opin Biol Ther       Date:  2010-10       Impact factor: 4.388

6.  Replication-defective bovine adenovirus type 3 as an expression vector.

Authors:  P S Reddy; N Idamakanti; Y Chen; T Whale; L A Babiuk; M Mehtali; S K Tikoo
Journal:  J Virol       Date:  1999-11       Impact factor: 5.103

7.  Comparative analysis of vector biodistribution, persistence and gene expression following intravenous delivery of bovine, porcine and human adenoviral vectors in a mouse model.

Authors:  Anurag Sharma; Dinesh S Bangari; Manish Tandon; Aseem Pandey; Harm HogenEsch; Suresh K Mittal
Journal:  Virology       Date:  2009-02-10       Impact factor: 3.616

8.  The fibre of bovine adenovirus type 3 is very long but bent.

Authors:  R W Ruigrok; A Barge; S K Mittal; B Jacrot
Journal:  J Gen Virol       Date:  1994-08       Impact factor: 3.891

9.  Pathology and immunogenicity in the cotton rat (Sigmodon hispidus) model after infection with a bovine adenovirus type 3 recombinant virus expressing the firefly luciferase gene.

Authors:  S K Mittal; D M Middleton; S K Tikoo; L Prevec; F L Graham; L A Babiuk
Journal:  J Gen Virol       Date:  1996-01       Impact factor: 3.891

10.  The InterPro protein families database: the classification resource after 15 years.

Authors:  Alex Mitchell; Hsin-Yu Chang; Louise Daugherty; Matthew Fraser; Sarah Hunter; Rodrigo Lopez; Craig McAnulla; Conor McMenamin; Gift Nuka; Sebastien Pesseat; Amaia Sangrador-Vegas; Maxim Scheremetjew; Claudia Rato; Siew-Yit Yong; Alex Bateman; Marco Punta; Teresa K Attwood; Christian J A Sigrist; Nicole Redaschi; Catherine Rivoire; Ioannis Xenarios; Daniel Kahn; Dominique Guyot; Peer Bork; Ivica Letunic; Julian Gough; Matt Oates; Daniel Haft; Hongzhan Huang; Darren A Natale; Cathy H Wu; Christine Orengo; Ian Sillitoe; Huaiyu Mi; Paul D Thomas; Robert D Finn
Journal:  Nucleic Acids Res       Date:  2014-11-26       Impact factor: 16.971
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.