Literature DB >> 28084848

The intriguing role of soluble urokinase receptor in inflammatory diseases.

S Desmedt1, V Desmedt1, J R Delanghe2, R Speeckaert2, M M Speeckaert1.   

Abstract

Inflammation is a key player in the development of an increasing amount of diseases. The soluble urokinase plasminogen activator receptor (suPAR) is a highly flexible molecule with intrinsic chemotactic properties. This glycoprotein has been evaluated as a biomarker of inflammation, immune activation, organ damage and clinical outcome in several pathologies, including cardiovascular disease, hepatitis, renal disorders and rheumatic pathologies. The use of this early warning inflammatory biomarker could potentially improve the prediction of the severity of these diseases and mortality. In the present paper, we describe the general characteristics of suPAR and its intriguing role as a biomarker in different inflammatory diseases.

Entities:  

Keywords:  Biomarker; chemotaxis; immune activation; inflammation; soluble urokinase plasminogen activator receptor

Mesh：

Substances：

Year:  2017        PMID： 28084848     DOI： 10.1080/10408363.2016.1269310

Source DB:  PubMed          Journal:  Crit Rev Clin Lab Sci        ISSN： 1040-8363            Impact factor:   6.250


  23 in total

1.  Increased soluble urokinase plasminogen activator receptor (suPAR) levels in neovascular age-related macular degeneration: a role for inflammation in the pathogenesis of the disease?

Authors:  Fabrizio Scotti; Paolo Milani; Marco Setaccioli; Silvia Maestroni; Nicolai Sidenius; Valentina De Lorenzi; Amedeo Massacesi; Fulvio Bergamini; Gianpaolo Zerbini
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2019-01-07       Impact factor: 3.117

Review 2.  The Expanding Role of Biomarkers in Diagnosing Infection in Total Joint Arthroplasty: A Review of Current Literature.

Authors:  Ardalan Sayan; Adam Kopiec; Alisina Shahi; Madhav Chowdhry; Matthew Bullock; Ali Oliashirazi
Journal:  Arch Bone Jt Surg       Date:  2021-01

3.  Mechanisms underlying modulation of podocyte TRPC6 channels by suPAR: Role of NADPH oxidases and Src family tyrosine kinases.

Authors:  Eun Young Kim; Naghmeh Hassanzadeh Khayyat; Stuart E Dryer
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2018-08-08       Impact factor: 5.187

4.  Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood.

Authors:  Line Jee Hartmann Rasmussen; Terrie E Moffitt; Jesper Eugen-Olsen; Daniel W Belsky; Andrea Danese; HonaLee Harrington; Renate M Houts; Richie Poulton; Karen Sugden; Benjamin Williams; Avshalom Caspi
Journal:  J Child Psychol Psychiatry       Date:  2018-05-09       Impact factor: 8.982

5.  Use of the prognostic biomarker suPAR in the emergency department improves risk stratification but has no effect on mortality: a cluster-randomized clinical trial (TRIAGE III).

Authors:  Martin Schultz; Line Jee Hartmann Rasmussen; Malene H Andersen; Jakob S Stefansson; Alexander C Falkentoft; Morten Alstrup; Andreas Sandø; Sarah L K Holle; Jeppe Meyer; Peter B S Törnkvist; Thomas Høi-Hansen; Erik Kjøller; Birgitte Nybo Jensen; Morten Lind; Lisbet Ravn; Thomas Kallemose; Theis Lange; Lars Køber; Lars Simon Rasmussen; Jesper Eugen-Olsen; Kasper Karmark Iversen
Journal:  Scand J Trauma Resusc Emerg Med       Date:  2018-08-28       Impact factor: 2.953

6.  Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor.

Authors:  Joseph Dowsett; Egil Ferkingstad; Line Jee Hartmann Rasmussen; Lise Wegner Thørner; Magnús K Magnússon; Karen Sugden; Gudmar Thorleifsson; Mike Frigge; Kristoffer Sølvsten Burgdorf; Sisse Rye Ostrowski; Erik Sørensen; Christian Erikstrup; Ole Birger Pedersen; Thomas Folkmann Hansen; Karina Banasik; Søren Brunak; Vinicius Tragante; Sigrun Helga Lund; Lilja Stefansdottir; Bjarni Gunnarson; Richie Poulton; Louise Arseneault; Avshalom Caspi; Terrie E Moffitt; Daníel Gudbjartsson; Jesper Eugen-Olsen; Hreinn Stefánsson; Kári Stefánsson; Henrik Ullum
Journal:  Commun Biol       Date:  2021-06-02

7.  Linking stressful life events and chronic inflammation using suPAR (soluble urokinase plasminogen activator receptor).

Authors:  Kyle J Bourassa; Line J H Rasmussen; Andrea Danese; Jesper Eugen-Olsen; HonaLee Harrington; Renate Houts; Richie Poulton; Sandhya Ramrakha; Karen Sugden; Ben Williams; Terrie E Moffitt; Avshalom Caspi
Journal:  Brain Behav Immun       Date:  2021-07-02       Impact factor: 19.227

8.  suPAR is associated with risk of future acute surgery and post-operative mortality in acutely admitted medical patients.

Authors:  Jeppe Meyer; Morten Alstrup; Line J H Rasmussen; Martin Schultz; Steen Ladelund; Thomas H Haupt; Jens Tingleff; Kasper Iversen; Jesper Eugen-Olsen
Journal:  Scand J Trauma Resusc Emerg Med       Date:  2018-02-01       Impact factor: 2.953

9.  suPAR as a marker of infection in acute kidney injury - a prospective observational study.

Authors:  Anna Hall; Siobhan Crichton; Matt Varrier; Danielle E Bear; Marlies Ostermann
Journal:  BMC Nephrol       Date:  2018-08-02       Impact factor: 2.388

10.  Combining National Early Warning Score With Soluble Urokinase Plasminogen Activator Receptor (suPAR) Improves Risk Prediction in Acute Medical Patients: A Registry-Based Cohort Study.

Authors:  Line J H Rasmussen; Steen Ladelund; Thomas H Haupt; Gertrude E Ellekilde; Jesper Eugen-Olsen; Ove Andersen
Journal:  Crit Care Med       Date:  2018-12       Impact factor: 7.598
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.