| Literature DB >> 28084189 |
Aimalohi A Ahonkhai1,2,3, Juliet Adeola4, Bolanle Banigbe4, Ifeyinwa Onwuatuelo4, Abdulkabir B Adegoke2, Ingrid V Bassett1,2,3,5, Elena Losina2,3,5,6,7, Kenneth A Freedberg1,2,3,5,8,9,10, Prosper Okonkwo3, Susan Regan2,5,8.
Abstract
The authors conducted a retrospective cohort study of unplanned care interruption (UCI) among adults initiating antiretroviral therapy (ART) from 2009 to 2011 in a Nigerian clinic. The authors used repeated measures regression to model the impact of UCI on CD4 count upon return to care and rate of CD4 change on ART. Among 2496 patients, 83% had 0, 15% had 1, and 2% had ≥2 UCIs. Mean baseline CD4 for those with 0, 1, or ≥2 UCIs was 228/cells/mm3, 355/cells/mm3, and 392/cells/mm3 ( P < .0001), respectively. The UCI was associated with a 62 CD4 cells/mm3 decrease (95% confidence interval [CI]: -78 to -45) at next measurement. In months 1 to 6 on ART, patients with 0 UCI gained 10 cells/µL/mo (95% CI: 7-4). Those with 1 and ≥2 UCIs lost 2 and 5 cells/µL/mo (95% CI: -18 to 13 and -26 to 16). Patients with UCI did not recover from early CD4 losses associated with UCI. Preventing UCI is critical to maximize benefits of ART.Entities:
Keywords: CD4; HIV infection; adherence; care interruption; immunologic recovery
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Year: 2016 PMID： 28084189 PMCID： PMC5289066 DOI： 10.1177/2325957416672010
Source DB: PubMed Journal: J Int Assoc Provid AIDS Care ISSN： 2325-9574