Martin Barrio1, Johannes Czernin1, Stefano Fanti2, Valentina Ambrosini2, Ina Binse3, Lin Du4, Matthias Eiber1, Ken Herrmann5,3, Wolfgang P Fendler1,6. 1. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California. 2. Nuclear Medicine Unit, University of Bologna, S. Orsola Hospital Bologna, Bologna, Italy. 3. Department of Nuclear Medicine, University Hospital Essen, Essen, Germany. 4. Department of Biostatistics, David Geffen School of Medicine at UCLA, Los Angeles, California; and. 5. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California kherrmann@mednet.ucla.edu. 6. Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany.
Abstract
Somatostatin receptor (SSTR) imaging is widely used for guiding the management of neuroendocrine tumor (NET) patients. 68Ga-DOTATATE approval by the U.S. Food and Drug Administration has triggered widespread clinical interest in SSTR PET/CT throughout the United States. Here, we performed a systematic review and meta-analysis to evaluate the impact of SSTR PET/CT on the management of patients with NETs. Methods: A comprehensive literature search was performed using The National Center for Biotechnology Information PubMed online database, applying the following key words: "management" AND "PET" AND "neuroendocrine". Fourteen of 190 studies were deemed suitable based on the following inclusion criteria: original research, cohort study, number of patients 10 or more, and reported change in management after SSTR PET/CT. Change in management across studies was determined by a random-effects model. Results: A total of 1,561 patients were included. Overall, change in management occurred in 44% (range, 16%-71%) of NET patients after SSTR PET/CT. In 4 of 14 studies, SSTR PET/CT was performed after an 111In-Octreotide scan. In this subgroup, additional information by SSTR PET/CT led to a change in management in 39% (range, 16%-71%) of patients. Seven of 14 studies differentiated between inter- and intramodality changes, with most changes being intermodality (77%; intramodality, 23%). Conclusion: The management was changed in more than one third of patients undergoing SSTR PET/CT even when performed after an 111In-Octreotide scan. Intermodality changes were 3 times more likely than intramodality changes, underlining the clinical impact of SSTR PET/CT.
Somatostatin receptor (SSTR) imaging is widely used for guiding the management of neuroendocrine tumor (NET) patients. 68Ga-DOTATATE approval by the U.S. Food and Drug Administration has triggered widespread clinical interest in SSTR PET/CT throughout the United States. Here, we performed a systematic review and meta-analysis to evaluate the impact of SSTR PET/CT on the management of patients with NETs. Methods: A comprehensive literature search was performed using The National Center for Biotechnology Information PubMed online database, applying the following key words: "management" AND "PET" AND "neuroendocrine". Fourteen of 190 studies were deemed suitable based on the following inclusion criteria: original research, cohort study, number of patients 10 or more, and reported change in management after SSTR PET/CT. Change in management across studies was determined by a random-effects model. Results: A total of 1,561 patients were included. Overall, change in management occurred in 44% (range, 16%-71%) of NET patients after SSTR PET/CT. In 4 of 14 studies, SSTR PET/CT was performed after an 111In-Octreotide scan. In this subgroup, additional information by SSTR PET/CT led to a change in management in 39% (range, 16%-71%) of patients. Seven of 14 studies differentiated between inter- and intramodality changes, with most changes being intermodality (77%; intramodality, 23%). Conclusion: The management was changed in more than one third of patients undergoing SSTR PET/CT even when performed after an 111In-Octreotide scan. Intermodality changes were 3 times more likely than intramodality changes, underlining the clinical impact of SSTR PET/CT.
Authors: Christina Pfannenberg; Brigitte Gueckel; Lisa Wang; Sergios Gatidis; Susann-Cathrin Olthof; Werner Vach; Matthias Reimold; Christian la Fougere; Konstantin Nikolaou; Peter Martus Journal: Eur J Nucl Med Mol Imaging Date: 2018-09-29 Impact factor: 9.236
Authors: Jeremie Calais; Johannes Czernin; Matthias Eiber; Wolfgang P Fendler; Jeannine Gartmann; Anthony P Heaney; Andrew E Hendifar; Joseph R Pisegna; J Randolph Hecht; Edward M Wolin; Roger Slavik; Pawan Gupta; Andrew Quon; Christiaan Schiepers; Martin S Allen-Auerbach; Ken Herrmann Journal: J Nucl Med Date: 2017-05-04 Impact factor: 10.057
Authors: Thomas A Hope; Emily K Bergsland; Murat Fani Bozkurt; Michael Graham; Anthony P Heaney; Ken Herrmann; James R Howe; Matthew H Kulke; Pamela L Kunz; Josh Mailman; Lawrence May; David C Metz; Corina Millo; Sue O'Dorisio; Diane L Reidy-Lagunes; Michael C Soulen; Jonathan R Strosberg Journal: J Nucl Med Date: 2017-10-12 Impact factor: 10.057