| Literature DB >> 28082101 |
Dimitri A de Kouchkovsky1, Sourav Ghosh2, Carla V Rothlin3.
Abstract
Type 2 immunity encompasses the mechanisms through which the immune system responds to helminths and an array of environmental substances such as allergens. In the developing world, billions of individuals are chronically infected with endemic parasitic helminths. In comparison, in the industrialized world, millions of individuals suffer from dysregulated type 2 immunity, referred to clinically as atopic diseases including asthma, allergic rhinitis, and atopic dermatitis. Thus, type 2 immunity must be carefully regulated to mount protective host responses yet avoid inappropriate activation and immunopathology. In this review, we describe the key players and connections at play in type 2 responses and focus on the emerging mechanisms involved in the negative regulation of type 2 immunity.Entities:
Mesh：
Substances：
Year: 2017 PMID： 28082101 PMCID： PMC5510550 DOI： 10.1016/j.it.2016.12.002
Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687