Isolation and characterization of thioxamycin.

A new peptide antibiotic named thioxamycin which contained thiazole and oxazole rings was isolated from the culture broth of Streptomyces sp. The antibiotic is acidic and lipophilic in nature. A molecular formula, C52H48N16O15S4, was indicated by elemental analysis and MS. One mol of threonine and three unusual amino acids were detected by amino acid analysis of the acid hydrolysate. The antibiotic is active in vitro against anaerobic Gram-positive and Gram-negative bacteria and also aerobic Gram-positive bacteria.