Na Du1, Feng Wang1. 1. Department of Infectious Diseases, The First Affiliated Hospital of Jilin University, Changchun, P.R. China.
Abstract
BACKGROUND/AIM: Brucella endocarditis, which is a rare condition, is the most common cause of death in human brucellosis, leading to severe cardiac complications. By collecting and analyzing clinical cases, we analyzed the clinical characteristics and outcome of Brucella endocarditis in endemic areas in China. MATERIALS AND METHODS: Presented here are 5 cases of Brucella endocarditis, all managed uniformly. We present the clinical, serological, and echocardiographic features; the therapeutic approach; and the follow-up of five patients with Brucella endocarditis. RESULTS: There was a predominance of aortic involvement (4 cases) and a high incidence of left ventricular failure (5 cases). Polymerase chain reaction (PCR) testing was positive in all five patients. Diagnostic suspicion was essential in order to test blood cultures correctly, which in this series were positive in 3 patients. In the follow-up postoperative period of a minimum of 24 months, the patients suffered rare relapse in terms of either the infection or the dysfunction in terms of prosthesis after 3-month antibiotic therapy, with only one exception that died within that period. CONCLUSION: We should pay attention to Brucella infections and strengthen public awareness and education. It is necessary to screen for and recognize Brucella endocarditis cases early and to provide adequate antibiotic treatment.
BACKGROUND/AIM: Brucella endocarditis, which is a rare condition, is the most common cause of death in humanbrucellosis, leading to severe cardiac complications. By collecting and analyzing clinical cases, we analyzed the clinical characteristics and outcome of Brucella endocarditis in endemic areas in China. MATERIALS AND METHODS: Presented here are 5 cases of Brucella endocarditis, all managed uniformly. We present the clinical, serological, and echocardiographic features; the therapeutic approach; and the follow-up of five patients with Brucella endocarditis. RESULTS: There was a predominance of aortic involvement (4 cases) and a high incidence of left ventricular failure (5 cases). Polymerase chain reaction (PCR) testing was positive in all five patients. Diagnostic suspicion was essential in order to test blood cultures correctly, which in this series were positive in 3 patients. In the follow-up postoperative period of a minimum of 24 months, the patients suffered rare relapse in terms of either the infection or the dysfunction in terms of prosthesis after 3-month antibiotic therapy, with only one exception that died within that period. CONCLUSION: We should pay attention to Brucella infections and strengthen public awareness and education. It is necessary to screen for and recognize Brucella endocarditis cases early and to provide adequate antibiotic treatment.