Un Chul Park1, In Hwan Cho1, Sang Woong Moon2, Hyeong Gon Yu1,3. 1. a Department of Ophthalmology , College of Medicine, Seoul National University , Seoul , Korea. 2. b Department of Ophthalmology , Kyung Hee University School of Medicine , Seoul , Korea. 3. c Sensory Organs Institute, Medical Research Center, Seoul National University , Seoul , Korea.
Abstract
PURPOSE: To evaluate long-term changes of subfoveal choroidal thickness (SCT) in Behçet's disease (BD) patients with posterior uveitis. METHODS: Changes in SCT measured with enhanced depth imaging optical coherence tomography during quiescent phase were assessed during >24 months in 63 BD patients and control group. RESULTS: Baseline characteristics showed no difference, but the BD group showed poorer visual acuity (p = 0.013) and smaller SCT (p = 0.006) at final examination. Mean SCT in the BD group decreased from 291.0 to 268.1 μm (p<0.001) during the mean period of 38.5 months. Mean change rate of SCT in the BD group was greater than controls (-7.2 vs 2.0 μm/year; p<0.001) and was associated with longer active inflammation (p<0.001). Patients with longer disease duration showed smaller baseline SCT (p = 0.03). CONCLUSIONS: In BD patients, choroidal thickness decreased over time, which was associated with length of active inflammation. It suggests intraocular inflammation in BD affects the choroid as well as the retina.
PURPOSE: To evaluate long-term changes of subfoveal choroidal thickness (SCT) in Behçet's disease (BD) patients with posterior uveitis. METHODS: Changes in SCT measured with enhanced depth imaging optical coherence tomography during quiescent phase were assessed during >24 months in 63 BD patients and control group. RESULTS: Baseline characteristics showed no difference, but the BD group showed poorer visual acuity (p = 0.013) and smaller SCT (p = 0.006) at final examination. Mean SCT in the BD group decreased from 291.0 to 268.1 μm (p<0.001) during the mean period of 38.5 months. Mean change rate of SCT in the BD group was greater than controls (-7.2 vs 2.0 μm/year; p<0.001) and was associated with longer active inflammation (p<0.001). Patients with longer disease duration showed smaller baseline SCT (p = 0.03). CONCLUSIONS: In BD patients, choroidal thickness decreased over time, which was associated with length of active inflammation. It suggests intraocular inflammation in BD affects the choroid as well as the retina.
Authors: Samantha Sze-Yee Lee; David Alonso-Caneiro; Gareth Lingham; Fred K Chen; Paul G Sanfilippo; Seyhan Yazar; David A Mackey Journal: Invest Ophthalmol Vis Sci Date: 2022-05-02 Impact factor: 4.925
Authors: Samantha Sze-Yee Lee; Darren John Beales; Fred K Chen; Seyhan Yazar; David Alonso-Caneiro; David A Mackey Journal: Sci Rep Date: 2021-03-17 Impact factor: 4.379