Rongfeng Dai1, Guohua Deng2, Zhuo Sun2, Zhinan Liu2, Yu Qian1, Yan Han1. 1. Department of Endocrinology, The Third People's Hospital of Changzhou, Changzhou, China. 2. Department of Ophthalmology, The Third People's Hospital of Changzhou, Changzhou, China.
Abstract
OBJECTIVE: Nesfatin-1, belonging to adipokine family, serves as an anti-inflammatory mediator. We performed this investigation to evaluate the relation between serum and vitreous nesfatin-1 concentrations with diabetic retinopathy (DR). METHODS: This study was performed in a population of 189 diabetic patients and 48 control subjects. Diabetic patients were then divided into diabetic patients without DR, non-proliferative diabetic retinopathy (NPDR) patients, and proliferative diabetic retinopathy (PDR) patients. RESULTS: Serum and vitreous nesfatin-1 concentrations were significantly lower in the diabetic patients than in the controls. NPDR patients had reduced vitreous nesfatin-1 concentrations compared with patients without DR. In addition, there were significantly lower serum and vitreous nesfatin-1 concentrations in PDR patients compared with the other three groups. Pearson correlation analysis showed that serum nesfatin-1 was negatively correlated with body mass index and fasting plasma glucose in diabetic patients. CONCLUSION: Serum and vitreous nesfatin-1 concentrations were negatively correlated with DR.
OBJECTIVE:Nesfatin-1, belonging to adipokine family, serves as an anti-inflammatory mediator. We performed this investigation to evaluate the relation between serum and vitreous nesfatin-1 concentrations with diabetic retinopathy (DR). METHODS: This study was performed in a population of 189 diabeticpatients and 48 control subjects. Diabeticpatients were then divided into diabeticpatients without DR, non-proliferative diabetic retinopathy (NPDR) patients, and proliferative diabetic retinopathy (PDR) patients. RESULTS: Serum and vitreous nesfatin-1 concentrations were significantly lower in the diabeticpatients than in the controls. NPDR patients had reduced vitreous nesfatin-1 concentrations compared with patients without DR. In addition, there were significantly lower serum and vitreous nesfatin-1 concentrations in PDR patients compared with the other three groups. Pearson correlation analysis showed that serum nesfatin-1 was negatively correlated with body mass index and fasting plasma glucose in diabeticpatients. CONCLUSION: Serum and vitreous nesfatin-1 concentrations were negatively correlated with DR.
Authors: Ronald Gonzalez; Benjamin K Reingold; Xiaodong Gao; Mandeep P Gaidhu; Robert G Tsushima; Suraj Unniappan Journal: J Endocrinol Date: 2011-01-11 Impact factor: 4.286
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Authors: C P Wilkinson; Frederick L Ferris; Ronald E Klein; Paul P Lee; Carl David Agardh; Matthew Davis; Diana Dills; Anselm Kampik; R Pararajasegaram; Juan T Verdaguer Journal: Ophthalmology Date: 2003-09 Impact factor: 12.079