Literature DB >> 28079292

Germ cell tumors: Insights from the Drosophila ovary and the mouse testis.

Helen K Salz1, Emily P Dawson2, Jason D Heaney2.   

Abstract

Ovarian and testicular germ cell tumors of young adults are thought to arise from defects in germ cell development, but the molecular mechanisms underlying malignant transformation are poorly understood. In this review, we focus on the biology of germ cell tumor formation in the Drosophila ovary and the mouse testis, for which evidence supports common underlying mechanisms, such as blocking initiation into the differentiation pathway, impaired lineage progression, and sexual identity instability. We then discuss how these concepts inform our understanding of the disease in humans. Mol. Reprod. Dev. 84: 200-211, 2017.
© 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

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Mesh：

Year:  2017        PMID： 28079292      PMCID： PMC5365366          DOI： 10.1002/mrd.22779

Source DB:  PubMed          Journal:  Mol Reprod Dev        ISSN： 1040-452X            Impact factor:   2.609


  134 in total

1.  Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling.

Authors:  N Tulina; E Matunis
Journal:  Science       Date:  2001-12-21       Impact factor: 47.728

2.  Phf7 controls male sex determination in the Drosophila germline.

Authors:  Shu Yuan Yang; Ellen M Baxter; Mark Van Doren
Journal:  Dev Cell       Date:  2012-05-15       Impact factor: 12.270

3.  Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue.

Authors:  A A Kiger; D L Jones; C Schulz; M B Rogers; M T Fuller
Journal:  Science       Date:  2001-12-21       Impact factor: 47.728

4.  Nanos2 suppresses meiosis and promotes male germ cell differentiation.

Authors:  Atsushi Suzuki; Yumiko Saga
Journal:  Genes Dev       Date:  2008-02-15       Impact factor: 11.361

5.  Pten is essential for embryonic development and tumour suppression.

Authors:  A Di Cristofano; B Pesce; C Cordon-Cardo; P P Pandolfi
Journal:  Nat Genet       Date:  1998-08       Impact factor: 38.330

6.  Jak/Stat signalling in niche support cells regulates dpp transcription to control germline stem cell maintenance in the Drosophila ovary.

Authors:  Lourdes López-Onieva; Ana Fernández-Miñán; Acaimo González-Reyes
Journal:  Development       Date:  2008-01-02       Impact factor: 6.868

7.  Drosophila piwi mutants exhibit germline stem cell tumors that are sustained by elevated Dpp signaling.

Authors:  Zhigang Jin; Alex S Flynt; Eric C Lai
Journal:  Curr Biol       Date:  2013-07-25       Impact factor: 10.834

8.  Female sterile mutations on the second chromosome of Drosophila melanogaster. I. Maternal effect mutations.

Authors:  T Schüpbach; E Wieschaus
Journal:  Genetics       Date:  1989-01       Impact factor: 4.562

9.  Drosophila glypicans regulate the germline stem cell niche.

Authors:  Yoshiki Hayashi; Satoru Kobayashi; Hiroshi Nakato
Journal:  J Cell Biol       Date:  2009-11-09       Impact factor: 10.539

10.  The JAK/STAT pathway positively regulates DPP signaling in the Drosophila germline stem cell niche.

Authors:  Liwei Wang; Zhouhua Li; Yu Cai
Journal:  J Cell Biol       Date:  2008-02-18       Impact factor: 10.539
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  4 in total

1.  An autoregulatory switch in sex-specific phf7 transcription causes loss of sexual identity and tumors in the Drosophila female germline.

Authors:  Anne E Smolko; Laura Shapiro-Kulnane; Helen K Salz
Journal:  Development       Date:  2020-09-11       Impact factor: 6.862

2.  The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells.

Authors:  Anne E Smolko; Laura Shapiro-Kulnane; Helen K Salz
Journal:  Nat Commun       Date:  2018-10-08       Impact factor: 14.919

Review 3.  Predicting Gonadal Germ Cell Cancer in People with Disorders of Sex Development; Insights from Developmental Biology.

Authors:  Leendert H J Looijenga; Chia-Sui Kao; Muhammad T Idrees
Journal:  Int J Mol Sci       Date:  2019-10-10       Impact factor: 5.923

4.  Stonewall prevents expression of ectopic genes in the ovary and accumulates at insulator elements in D. melanogaster.

Authors:  Daniel Zinshteyn; Daniel A Barbash
Journal:  PLoS Genet       Date:  2022-03-24       Impact factor: 5.917
  4 in total

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