Literature DB >> 28078046

Effects of etomidate and propofol on immune function in patients with lung adenocarcinoma.

Jiapeng Liu1, Wei Dong1, Tao Wang1, Liang Liu1, Long Zhan1, Yifei Shi1, Jiange Han1.   

Abstract

OBJECTIVE: To investigate the effects of etomidate and propofol on immune function in patients with lung adenocarcinoma.
METHODS: Sixty patients who were scheduled for lung cancer surgery under general anesthesia were studied. The patients were randomly divided into an etomidate total intravenous anesthesia group (group E) and a propofol total intravenous anesthesia group (group P), with 30 cases in each group.
RESULTS: Within group comparison: The percentage of CD4+ in the two groups was significantly reduced at 24 hours post-operation (T2) compared with the percentage before surgery, whereas the percentage of CD8+ was higher at T2. Between group comparison: The CD4+ percentage of group E was higher than that of group P (P < 0.05) at T2, whereas the CD8+ percentage was lower than that of group P (P < 0.05) at T1.
CONCLUSION: Using etomidate for anesthesia has less of an effect on immune function in patients with lung adenocarcinoma.

Entities:  

Keywords:  Etomidate; general anesthesia; immune function; lung adenocarcinoma; propofol

Year:  2016        PMID： 28078046      PMCID： PMC5209526     

Source DB:  PubMed          Journal:  Am J Transl Res            Impact factor:   4.060


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