Literature DB >> 28076767

(S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity.

Tibor Harkany1, Tamas L Horvath2.   

Abstract

Classical views posit G protein-coupled cannabinoid receptor 1s (CB1Rs) at the cell surface with cytosolic Giα-mediated signal transduction. Hebert-Chatelain et al. (2016) instead place CB1Rs at mitochondria limiting neuronal respiration by soluble adenylyl cyclase-dependent modulation of complex I activity. Thus, neuronal bioenergetics link to synaptic plasticity and, globally, learning and memory.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  GPCR; THC; axonal growth; bioenergetics; cannabinoid; cannabinoid receptor 1; cannabis; endocannabinoid; mitochondrial import; respiration

Mesh：

Substances：

Year:  2017        PMID： 28076767     DOI： 10.1016/j.cmet.2016.12.020

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  15 in total

1.  Intracellular GPCRs Play Key Roles in Synaptic Plasticity.

Authors:  Yuh-Jiin I Jong; Steven K Harmon; Karen L O'Malley
Journal:  ACS Chem Neurosci       Date:  2018-02-16       Impact factor: 4.418

2.  Chronic insulinopenia/hyperglycemia decreases cannabinoid CB1 receptor density and impairs glucose uptake in the mouse forebrain.

Authors:  Liane I F Moura; Cristina Lemos; Catherine Ledent; Eugénia Carvalho; Attila Köfalvi
Journal:  Brain Res Bull       Date:  2019-02-02       Impact factor: 4.077

Review 3.  Metabolic Messengers: endocannabinoids.

Authors:  Arnau Busquets-García; Juan P Bolaños; Giovanni Marsicano
Journal:  Nat Metab       Date:  2022-07-11

Review 4.  Melatonin and cannabinoids: mitochondrial-targeted molecules that may reduce inflammaging in neurodegenerative diseases.

Authors:  Sebastián García; Virna Margarita Martín Giménez; Feres José Mocayar Marón; Russel J Reiter; Walter Manucha
Journal:  Histol Histopathol       Date:  2020-03-10       Impact factor: 2.303

Review 5.  Mitochondria, Oxytocin, and Vasopressin: Unfolding the Inflammatory Protein Response.

Authors:  Evan A Bordt; Caroline J Smith; Tyler G Demarest; Staci D Bilbo; Marcy A Kingsbury
Journal:  Neurotox Res       Date:  2018-09-27       Impact factor: 3.911

Review 6.  Cannabinoid Receptor Signaling in Central Regulation of Feeding Behavior: A Mini-Review.

Authors:  Marco Koch
Journal:  Front Neurosci       Date:  2017-05-24       Impact factor: 4.677

7.  3-Hydroxypropane-1,2-Diyl Dipalmitoleate-A Natural Compound with Dual Roles (CB1 Agonist/FAAH1 Blocker) in Inhibiting Ovarian Cancer Cell Line.

Authors:  Christina Vijayaraghavan Sathynathan; Lakshmi Sundaram Raman; Sivamurugan Vajiravelu; Thirumal D Kumar; Thyagarajan Sadras Panchatcharam; Gopinathan Narasimhan; George C Priya Doss; Mary Elizabeth Gnanambal Krishnan
Journal:  Pharmaceuticals (Basel)       Date:  2021-03-12

Review 8.  CB1 Receptor Signaling in the Brain: Extracting Specificity from Ubiquity.

Authors:  Arnau Busquets-Garcia; Jaideep Bains; Giovanni Marsicano
Journal:  Neuropsychopharmacology       Date:  2017-09-01       Impact factor: 7.853

Review 9.  A Systematic Review of the Complex Effects of Cannabinoids on Cerebral and Peripheral Circulation in Animal Models.

Authors:  J Sebastian Richter; Véronique Quenardelle; Olivier Rouyer; Jean Sébastien Raul; Rémy Beaujeux; Bernard Gény; Valérie Wolff
Journal:  Front Physiol       Date:  2018-05-29       Impact factor: 4.566

Review 10.  Cannabinoid-Induced Immunomodulation during Viral Infections: A Focus on Mitochondria.

Authors:  Cherifa Beji; Hamza Loucif; Roman Telittchenko; David Olagnier; Xavier Dagenais-Lussier; Julien van Grevenynghe
Journal:  Viruses       Date:  2020-08-11       Impact factor: 5.048
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