Literature DB >> 28075053

Synthesis, Characterization and Immunological Evaluation of Self-Adjuvanting Group A Streptococcal Vaccine Candidates Bearing Various Lipidic Adjuvanting Moieties.

Vincent Fagan1, Waleed M Hussein1, Mei Su1, Ashwini K Giddam1, Michael R Batzloff2, Michael F Good2, Istvan Toth1,3,4, Pavla Simerska1.   

Abstract

Four group A streptococcal glycolipopeptide vaccine candidates with different lipidic adjuvanting moieties were prepared and characterized. The immunogenicity of the compounds was evaluated by macrophage and dendritic cell uptake studies and by in vivo quantification of systemic IgG antibody by ELISA. Three of the candidates showed significant induction of the IgG response.
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords:  adjuvant; antigens; immunology; lipopeptide vaccine; toll-like receptor 2

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Year:  2017        PMID： 28075053     DOI： 10.1002/cbic.201600639

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  3 in total

1.  Vaccine Adjuvant Incorporation Strategy Dictates Peptide Amphiphile Micelle Immunostimulatory Capacity.

Authors:  Rui Zhang; Jake S Kramer; Josiah D Smith; Brittany N Allen; Caitlin N Leeper; Xiaolei Li; Logan D Morton; Fabio Gallazzi; Bret D Ulery
Journal:  AAPS J       Date:  2018-06-01       Impact factor: 4.009

2.  Structure-Activity Relationship Studies To Identify Affinity Probes in Bis-aryl Sulfonamides That Prolong Immune Stimuli.

Authors:  Michael Chan; Fitzgerald S Lao; Paul J Chu; Jonathan Shpigelman; Shiyin Yao; Jason Nan; Fumi Sato-Kaneko; Vicky Li; Tomoko Hayashi; Maripat Corr; Dennis A Carson; Howard B Cottam; Nikunj M Shukla
Journal:  J Med Chem       Date:  2019-10-25       Impact factor: 7.446

Review 3.  Recent Advances in the Development of Peptide Vaccines and Their Delivery Systems Against Group A Streptococcus.

Authors:  Armira Azuar; Wanli Jin; Saori Mukaida; Waleed M Hussein; Istvan Toth; Mariusz Skwarczynski
Journal:  Vaccines (Basel)       Date:  2019-07-01
  3 in total

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