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Literature DB >> 28074225

Recent advances in biotechnological applications of alcohol dehydrogenases.

Yu-Guo Zheng¹, Huan-Huan Yin², Dao-Fu Yu², Xiang Chen², Xiao-Ling Tang², Xiao-Jian Zhang², Ya-Ping Xue², Ya-Jun Wang², Zhi-Qiang Liu³.

Abstract

Alcohol dehydrogenases (ADHs), which belong to the oxidoreductase superfamily, catalyze the interconversion between alcohols and aldehydes or ketones with high stereoselectivity under mild conditions. ADHs are widely employed as biocatalysts for the dynamic kinetic resolution of racemic substrates and for the preparation of enantiomerically pure chemicals. This review provides an overview of biotechnological applications for ADHs in the production of chiral pharmaceuticals and fine chemicals.

Entities: Chemical

Keywords: Alcohol dehydrogenases; Biotechnological applications; Chiral pharmaceuticals; Fine chemicals

Mesh：

Substances：

Year: 2017 PMID： 28074225 DOI： 10.1007/s00253-016-8083-6

Source DB: PubMed Journal: Appl Microbiol Biotechnol ISSN： 0175-7598 Impact factor: 4.813

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Cited

19 in total

1. Enhanced L-methionine production by genetically engineered Escherichia coli through fermentation optimization.

Authors: Hai-Yan Zhou; Wang-Jie Wu; Kun Niu; Yue-Ying Xu; Zhi-Qiang Liu; Yu-Guo Zheng
Journal: 3 Biotech Date: 2019-02-19 Impact factor: 2.406

2. Asymmetric Hydrogenation of C = C Bonds in a SpinChem Reactor by Immobilized Old Yellow Enzyme and Glucose Dehydrogenase.

Authors: Teng Ma; Weixi Kong; Yunting Liu; Hao Zhao; Yaping Ouyang; Jing Gao; Liya Zhou; Yanjun Jiang
Journal: Appl Biochem Biotechnol Date: 2022-06-10 Impact factor: 3.094

3. Metabolic engineering of E. coli for the production of O-succinyl-l-homoserine with high yield.

Authors: Jian-Feng Huang; Bo Zhang; Zhen-Yang Shen; Zhi-Qiang Liu; Yu-Guo Zheng
Journal: 3 Biotech Date: 2018-07-09 Impact factor: 2.406

4. Biosynthesis of miglitol intermediate 6-(N-hydroxyethyl)-amino-6-deoxy-α-l-sorbofuranose by an improved d-sorbitol dehydrogenase from Gluconobacter oxydans.

Authors: Xia Ke; Ning-Ning Wang; Pan-Hong Yu; Yang-Hui Lu; Zhong-Ce Hu; Yu-Guo Zheng
Journal: 3 Biotech Date: 2018-04-28 Impact factor: 2.406

5. Ultrahigh-Throughput Detection of Enzymatic Alcohol Dehydrogenase Activity in Microfluidic Droplets with a Direct Fluorogenic Assay.

Authors: Miriam Klaus; Paul Jannis Zurek; Tomasz S Kaminski; Ahir Pushpanath; Katharina Neufeld; Florian Hollfelder
Journal: Chembiochem Date: 2021-10-13 Impact factor: 3.461

Recent advances in biotechnological applications of alcohol dehydrogenases.

1. Enhanced L-methionine production by genetically engineered Escherichia coli through fermentation optimization.

2. Asymmetric Hydrogenation of C = C Bonds in a SpinChem Reactor by Immobilized Old Yellow Enzyme and Glucose Dehydrogenase.

3. Metabolic engineering of E. coli for the production of O-succinyl-l-homoserine with high yield.

4. Biosynthesis of miglitol intermediate 6-(N-hydroxyethyl)-amino-6-deoxy-α-l-sorbofuranose by an improved d-sorbitol dehydrogenase from Gluconobacter oxydans.

5. Ultrahigh-Throughput Detection of Enzymatic Alcohol Dehydrogenase Activity in Microfluidic Droplets with a Direct Fluorogenic Assay.

6. Enzymatic characterization of a recombinant carbonyl reductase from Acetobacter sp. CCTCC M209061.

7. Immobilized and Free Cells of Geotrichum candidum for Asymmetric Reduction of Ketones: Stability and Recyclability.

8. Engineering substrate promiscuity in halophilic alcohol dehydrogenase (HvADH2) by in silico design.

9. Exploring the reversal of enantioselectivity on a zinc-dependent alcohol dehydrogenase.

10. Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering.