Literature DB >> 28073426

The Prevention and Treatment of Retinal Complications in Diabetes.

Susanne Gabriele Schorr1, Hans-Peter Hammes, Ulrich Alfons Müller, Heinz-Harald Abholz, Rüdiger Landgraf, Bernd Bertram.   

Abstract

BACKGROUND: Microvascular complications of diabetes mellitus can cause retino pathy and maculopathy, which can irreversibly damage vision and lead to blindness. The prevalence of retinopathy is 9-16% in patients with type 2 diabetes and 24-27% in patients with type 1 diabetes. 0.2-0.5% of diabetics are blind.
METHODS: The National Disease Management Guideline on the prevention and treatment of retinal complications in diabetes was updated according to recommendations developed by seven scientific medical societies and organizations and by patient representatives and then approved in a formal consensus process. These recommendations are based on international guidelines and systematic reviews of the literature.
RESULTS: Regular ophthalmological examinations enable the detection of retinopathy in early, better treatable stages. The control intervals should be based on the individual risk profile: 2 years for low-risk patients and 1 year for others, or even shorter depending on the severity of retinopathy. General risk factors for retinopathy include the duration of diabetes, the degree of hyperglycemia, hypertension, and diabetic nephropathy. The general, individually adapted treatment strategies are aimed at improving the risk profile. The most important specifically ophthalmological treatment recommendations are for panretinal laser coagulation in proliferative diabetic retinopathy and, in case of clinically significant diabetic macular edema with foveal involvement, for the intravitreal application of medications (mainly, vascular endothelial growth factor [VEGF] inhibitors), if an improvement of vision with this treatment is thought to be possible.
CONCLUSION: Regular, risk-adapted ophthalmological examinations, with standardized documentation of the findings for communication between ophthalmologists and the patients' treating primary care physicians/diabetologists, is essential for the prevention of diabetic retinal complications, and for their optimal treatment if they are already present.

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Year:  2016        PMID: 28073426      PMCID: PMC5241793          DOI: 10.3238/arztebl.2016.0816

Source DB:  PubMed          Journal:  Dtsch Arztebl Int        ISSN: 1866-0452            Impact factor:   5.594


  41 in total

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7.  The RESTORE study: ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema.

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Journal:  Ophthalmology       Date:  2011-04       Impact factor: 12.079

8.  Expanded 2-year follow-up of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema.

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Journal:  Ophthalmology       Date:  2011-04       Impact factor: 12.079

9.  Intraocular surgery in a large diabetes patient population: risk factors and surgical results.

Authors:  Christoffer Ostri
Journal:  Acta Ophthalmol       Date:  2014-05       Impact factor: 3.761

Review 10.  Extending the diabetic retinopathy screening interval beyond 1 year: systematic review.

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  11 in total

1.  In Reply.

Authors:  Susanne Gabriele Schorr
Journal:  Dtsch Arztebl Int       Date:  2017-04-21       Impact factor: 5.594

2.  Important Risk Factors Were Not Included.

Authors:  Dieter Schmidt
Journal:  Dtsch Arztebl Int       Date:  2017-04-21       Impact factor: 5.594

Review 3.  Applications and Current Medico-Legal Challenges of Telemedicine in Ophthalmology.

Authors:  Daniela Mazzuca; Massimiliano Borselli; Santo Gratteri; Giovanna Zampogna; Alessandro Feola; Marcello Della Corte; Francesca Guarna; Vincenzo Scorcia; Giuseppe Giannaccare
Journal:  Int J Environ Res Public Health       Date:  2022-05-05       Impact factor: 4.614

Review 4.  Markedly decreasing incidence of cause-specific blindness in Saxony (Eastern Germany).

Authors:  Heiner Claessen; Tatjana Kvitkina; Maria Narres; Christoph Trautner; Bernd Bertram; Andrea Icks
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2020-09-25       Impact factor: 3.117

5.  HMGB1 siRNA can reduce damage to retinal cells induced by high glucose in vitro and in vivo.

Authors:  Shuang Jiang; Xiaolong Chen
Journal:  Drug Des Devel Ther       Date:  2017-03-15       Impact factor: 4.162

Review 6.  Mechanistic Insight and Management of Diabetic Nephropathy: Recent Progress and Future Perspective.

Authors:  Rui Xue; Dingkun Gui; Liyang Zheng; Ruonan Zhai; Feng Wang; Niansong Wang
Journal:  J Diabetes Res       Date:  2017-03-13       Impact factor: 4.011

7.  Bilateral cytomegalovirus retinitis comorbid with diabetic macular edema.

Authors:  Yu-Jang Chao; Yi-Ming Huang; Yu-Chien Chung; De-Kuang Hwang; Shih-Jen Chen; Catherine Jui-Ling Liu
Journal:  Taiwan J Ophthalmol       Date:  2019 Apr-Jun

8.  Association of Bone Metabolism Indices and Bone Mineral Density with Diabetic Retinopathy in Elderly Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Inpatient Study in China.

Authors:  Xin Zhao; Lili Huo; Xiaofeng Yu; Xiaomei Zhang
Journal:  J Diabetes Res       Date:  2021-01-12       Impact factor: 4.011

9.  Baicalin improves podocyte injury in rats with diabetic nephropathy by inhibiting PI3K/Akt/mTOR signaling pathway.

Authors:  Yi Ou; Wenjuan Zhang; Shaopeng Chen; Haihua Deng
Journal:  Open Med (Wars)       Date:  2021-09-02

Review 10.  The Role of Inflammation in Diabetic Retinopathy.

Authors:  John V Forrester; Lucia Kuffova; Mirela Delibegovic
Journal:  Front Immunol       Date:  2020-11-06       Impact factor: 7.561

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