Eric Rivas1,2, Serina J McEntire3, David N Herndon1,2, Ronald P Mlcak1,2, Oscar E Suman1,2. 1. Shriners Hospitals for Children, The University of Texas Medical Branch, Galveston, TX, USA. 2. Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA. 3. College of Nursing and Health Sciences, Valdosta State University, Valdosta, GA, USA.
Abstract
OBJECTIVE: We tested the hypothesis that propranolol, a drug given to burn patients to reduce hypermetabolism/cardiac stress, may inhibit heat dissipation by changing the sensitivity of skin blood flow (SkBF) to local heating under neutral and hot conditions. METHODS: In a randomized double-blind study, a placebo was given to eight burned children, while propranolol was given to 13 burned children with similar characteristics (mean±SD: 11.9±3 years, 147±20 cm, 45±23 kg, 56±12% Total body surface area burned). Nonburned children (n=13, 11.4±3 years, 152±15 cm, 52±13 kg) served as healthy controls. A progressive local heating protocol characterized SkBF responses in burned and unburned skin and nonburned control skin under the two environmental conditions (23 and 34°C) via laser Doppler flowmetry. RESULTS:Resting SkBF was greater in burned and unburned skin compared to the nonburned control (main effect: skin, P<.0001; 57±32 burned; 38±36 unburned vs 9±8 control %SkBFmax ). No difference was found for maximal SkBF capacity to local heating between groups. Additionally, dose-response curves for the sensitivity of SkBF to local heating were not different among burned or unburned skin, and nonburned control skin (EC50 , P>.05) under either condition. CONCLUSION:Therapeutic propranolol does not negatively affect SkBF under neutral or hot environmental conditions and further compromise temperature regulation in burned children.
RCT Entities:
OBJECTIVE: We tested the hypothesis that propranolol, a drug given to burn patients to reduce hypermetabolism/cardiac stress, may inhibit heat dissipation by changing the sensitivity of skin blood flow (SkBF) to local heating under neutral and hot conditions. METHODS: In a randomized double-blind study, a placebo was given to eight burned children, while propranolol was given to 13 burned children with similar characteristics (mean±SD: 11.9±3 years, 147±20 cm, 45±23 kg, 56±12% Total body surface area burned). Nonburned children (n=13, 11.4±3 years, 152±15 cm, 52±13 kg) served as healthy controls. A progressive local heating protocol characterized SkBF responses in burned and unburned skin and nonburned control skin under the two environmental conditions (23 and 34°C) via laser Doppler flowmetry. RESULTS: Resting SkBF was greater in burned and unburned skin compared to the nonburned control (main effect: skin, P<.0001; 57±32 burned; 38±36 unburned vs 9±8 control %SkBFmax ). No difference was found for maximal SkBF capacity to local heating between groups. Additionally, dose-response curves for the sensitivity of SkBF to local heating were not different among burned or unburned skin, and nonburned control skin (EC50 , P>.05) under either condition. CONCLUSION: Therapeutic propranolol does not negatively affect SkBF under neutral or hot environmental conditions and further compromise temperature regulation in burned children.
Authors: Scott L Davis; Manabu Shibasaki; David A Low; Jian Cui; David M Keller; Gary F Purdue; John L Hunt; Brett D Arnoldo; Karen J Kowalske; Craig G Crandall Journal: J Burn Care Res Date: 2007 May-Jun Impact factor: 1.845
Authors: David Patsouris; Peter Qi; Abdikarim Abdullahi; Mile Stanojcic; Peter Chen; Alexandra Parousis; Saeid Amini-Nik; Marc G Jeschke Journal: Cell Rep Date: 2015-11-12 Impact factor: 9.423
Authors: Eric Rivas; Kevin Sanchez; Janos Cambiaso-Daniel; Ileana L Gutierrez; Joan Tran; David N Herndon; Oscar E Suman Journal: J Burn Care Res Date: 2018-08-17 Impact factor: 1.845
Authors: Viktoria Mertin; Patrick Most; Martin Busch; Stefan Trojan; Christian Tapking; Valentin Haug; Ulrich Kneser; Gabriel Hundeshagen Journal: Burns Trauma Date: 2022-09-23