Literature DB >> 28070816

Can oral isotretinoin be safely initiated and monitored in primary care? A case series.

D Buckley1, S Yoganathan2.   

Abstract

BACKGROUND: Oral isotretinoin has traditionally been prescribed only in secondary care for severe or resistant acne. AIMS: To explore whether this drug can be safely initiated and monitored in primary care by a GP with extra training in dermatology.
METHOD: One hundred consecutive patients who were started on oral isotretinoin therapy in a primary care centre were retrospectively reviewed.
RESULTS: One hundred percent of the patients with acne who completed their course of isotretinoin were cleared at the end of treatment. Twenty-three of the eighty-one patients (28%) who were followed-up after a mean of 5 years relapsed and eighteen (22%) had to have at least one more course of isotretinoin. Seventy-four of seventy-seven (96%) patients who had long-term follow-up were satisfied with the level of care they received in primary care.
CONCLUSION: This study suggests that oral isotretinoin can be safely initiated and monitored by a GP with a special interest in dermatology and experience in prescribing systemic retinoids.

Entities:  

Keywords:  Acne; General practice; Isotretinoin; Monitoring; Prescribing; Primary care

Mesh:

Substances:

Year:  2017        PMID: 28070816     DOI: 10.1007/s11845-016-1540-5

Source DB:  PubMed          Journal:  Ir J Med Sci        ISSN: 0021-1265            Impact factor:   1.568


  14 in total

1.  The quality of life in acne: a comparison with general medical conditions using generic questionnaires.

Authors:  E Mallon; J N Newton; A Klassen; S L Stewart-Brown; T J Ryan; A Y Finlay
Journal:  Br J Dermatol       Date:  1999-04       Impact factor: 9.302

Review 2.  Isotretinoin, depression and suicide: a review of the evidence.

Authors:  Parker Magin; Dimity Pond; Wayne Smith
Journal:  Br J Gen Pract       Date:  2005-02       Impact factor: 5.386

Review 3.  Acne: more than skin deep.

Authors:  J Ayer; N Burrows
Journal:  Postgrad Med J       Date:  2006-08       Impact factor: 2.401

4.  Advice on the safe introduction and continued use of isotretinoin in acne in the U.K. 2010.

Authors:  M J D Goodfield; N H Cox; A Bowser; J C McMillan; L G Millard; N B Simpson; A D Ormerod
Journal:  Br J Dermatol       Date:  2010-06       Impact factor: 9.302

5.  Two-sided confidence intervals for the single proportion: comparison of seven methods.

Authors:  R G Newcombe
Journal:  Stat Med       Date:  1998-04-30       Impact factor: 2.373

Review 6.  Epidemiology of acne vulgaris.

Authors:  K Bhate; H C Williams
Journal:  Br J Dermatol       Date:  2013-03       Impact factor: 9.302

Review 7.  Acne vulgaris.

Authors:  Annelise L Dawson; Robert P Dellavalle
Journal:  BMJ       Date:  2013-05-08

8.  Isotretinoin for acne vulgaris--10 years later: a safe and successful treatment.

Authors:  A M Layton; H Knaggs; J Taylor; W J Cunliffe
Journal:  Br J Dermatol       Date:  1993-09       Impact factor: 9.302

9.  Isotretinoin therapy and the incidence of acne relapse: a nested case-control study.

Authors:  L Azoulay; D Oraichi; A Bérard
Journal:  Br J Dermatol       Date:  2007-10-26       Impact factor: 9.302

10.  Isotretinoin exposure during pregnancy: a population-based study in The Netherlands.

Authors:  Ingeborg M Zomerdijk; Rikje Ruiter; Leanne M A Houweling; Ron M C Herings; Miriam C J M Sturkenboom; Sabine M J M Straus; Bruno H Stricker
Journal:  BMJ Open       Date:  2014-11-12       Impact factor: 2.692

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  1 in total

1.  GPs' practice and attitudes to initiating isotretinoin for acne vulgaris in Ireland: a cross-sectional questionnaire survey in primary care.

Authors:  Kevin Carmody; Martin Rouse; Dermot Nolan; Diarmuid Quinlan
Journal:  Br J Gen Pract       Date:  2020-08-27       Impact factor: 5.386

  1 in total

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